1-(4-chlorophenyl)-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-8-one

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吲哚萘啶生物碱
• 英文名称: 1-(4-chlorophenyl)-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-8-one
• 英文别名: 9-(4-chlorophenyl)-1,11-diazapentacyclo[10.7.1.02,7.08,20.013,18]icosa-2,4,6,8(20),9,11,13,15,17-nonaen-19-one
• 化学式: C₂₄H₁₃ClN₂O
• 分子量: 380.8
• InChiKey: OBVROWWKNWIHIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES<br/>[FR] MATÉRIAUX POUR DISPOSITIFS ÉLECTROLUMINESCENTS ORGANIQUES
  申请人：MERCK PATENT GMBH

  公开号：WO2020016264A1

  公开（公告）日：2020-01-23

  The present invention relates to compounds of the formula (1) and mixture comprising these compounds, which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds and mixtures.

  本发明涉及公式（1）的化合物和包含这些化合物的混合物，适用于电子设备，特别是有机电致发光器件，并且包括这些化合物和混合物的电子设备。
• [EN] SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS<br/>[FR] INHIBITEURS SÉLECTIFS DE VOIES IKK/NF-KB INDUITES PAR LE STRESS GÉNOTOXIQUE
  申请人：MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN HELMHOLTZ GEMEINSCHAFT

  公开号：WO2018087389A1

  公开（公告）日：2018-05-17

  The invention relates to chemical compounds and their use as a medicament in the treatment of a disease associated with genotoxic stress-induced I KK/NF-κΒ (NF-kappaB) activation, preferably in the treatment of a subject suffering from cancer exhibiting genotoxic stress-induced I KK/NF-κΒ activation. The invention further relates to a pharmaceutical composition comprising a compound of the invention for the treatment of a subject afflicted by a disease associated with genotoxic stress-induced I KK/NF-κΒ activation.

  这项发明涉及化合物及其作为药物在治疗与基因毒性应激诱导的I KK/NF-κΒ（NF-kappaB）激活相关疾病中的用途，优选用于治疗患有展现基因毒性应激诱导的I KK/NF-κΒ激活的癌症患者。该发明还涉及一种包含该发明化合物的药物组合物，用于治疗患有与基因毒性应激诱导的I KK/NF-κΒ激活相关疾病的患者。
• ORGANIC ELECTROLUMINESCENT DEVICES
  申请人：Parham Amir Hossain

  公开号：US20130053555A1

  公开（公告）日：2013-02-28

  The present invention relates to electronic devices, in particular organic electroluminescent devices, comprising compounds of the formula (1), and the corresponding compounds.

  本发明涉及电子设备，特别是有机电致发光器件，包括公式（1）的化合物及其相应的化合物。
• SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-KB PATHWAYS
  申请人：Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft

  公开号：EP3321264A1

  公开（公告）日：2018-05-16

  The invention relates to chemical compounds and their use as a medicament in the treatment of a disease associated with genotoxic stress-induced IKK/NF-κB (NF-kappaB) activation. The invention further relates to a pharmaceutical composition comprising a compound of the invention for the treatment of a subject afflicted by a disease associated with genotoxic stress-induced IKK/NF-κB activation.

  本发明涉及化合物及其在治疗与基因毒性应激诱导的 IKK/NF-κB（NF-kappaB）激活相关的疾病中作为药物的用途。本发明进一步涉及一种包含本发明化合物的药物组合物，用于治疗受基因毒性应激诱导的IKK/NF-κB活化相关疾病困扰的受试者。
• Selective inhibitors of gentotoxic steress-induced IKK/NF-κB pathways
  申请人：Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft

  公开号：US11028084B2

  公开（公告）日：2021-06-08

  A method is for treatment of a disease associated with genotoxic stress-induced inhibitor of nuclear factor-κB kinase/nuclear factor kappa-light chain enhancer of activated B cells (IKK/NF-κB) signaling. The method can include administering a compound to a subject having a cancer exhibiting genotoxic stress induced IKK/NF-κB activation.

  一种方法用于治疗与基因毒性应激诱导的核因子-κB激酶/活化B细胞的核因子卡巴轻链增强子（IKK/NF-κB）信号转导抑制有关的疾病。该方法可包括向患有基因毒性应激诱导的IKK/NF-κB活化的癌症的受试者施用一种化合物。