methyl psoromate | 60441-77-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: methyl psoromate
• 英文别名: Methyl-psoromat；4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid methyl ester；methyl 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylate
• CAS: 60441-77-2
• 化学式: C₁₉H₁₆O₈
• 分子量: 372.331
• InChiKey: SPPTYKIGBRRHMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  methyl psoromate 在 lithium iodide 、 盐酸 作用下， 以 六甲基磷酰三胺 、 水 为溶剂， 反应 26.0h， 生成 茶痂衣酸
  参考文献：
  名称：

  EP2199295

  摘要：

  公开号：
• 作为产物：
  描述：

  茶痂衣酸 、 硫酸二甲酯 在 potassium hydrogencarbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.75h， 以92%的产率得到methyl psoromate
  参考文献：
  名称：

  Elix, John A.; Venables, Debra A.; Brako, Lois, Australian Journal of Chemistry, 1990, vol. 43, p. 1953 - 1959

  摘要：

  DOI：

文献信息

• Heptacyclic compounds and the pharmaceutical uses thereof for preventing and treating diabetes and metabolic syndrome
  申请人：Shanghai Institute of Materia Medica Chinese Academy of Sciences

  公开号：US08158623B2

  公开（公告）日：2012-04-17

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明揭示了一类七环化合物在制备用于预防和治疗糖尿病和代谢综合征的配方中的新用途；本发明还揭示了一类新的七环化合物；本发明还揭示了制备七环化合物和含有七环化合物的组合物的方法。本发明的七环化合物可用于有效地预防或治疗糖尿病和代谢综合征等疾病。
• HEPTACYCLIC COMPOUNDS AND THE PHARMACEUTICAL USES THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLIC SYNDROME
  申请人：Shen Jianhua

  公开号：US20100173905A1

  公开（公告）日：2010-07-08

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明公开了一类七环化合物在制备用于预防和治疗糖尿病和代谢综合症的配方中的新用途；本发明还公开了一类新的七环化合物；本发明还公开了一种制备七环化合物和含有七环化合物的组成物的方法。本发明的七环化合物可用于有效地预防或治疗糖尿病和代谢综合症等疾病。
• COMPOUNDS WITH 7-MEMBER CYCLE AND THE PHARMACEUTICAL USE THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLISM SYNDROME
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP2199295A1

  公开（公告）日：2010-06-23

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明公开了一类庚环化合物在制备预防和治疗糖尿病和代谢综合征的制剂中的新用途；本发明还公开了一类新的庚环化合物；本发明还公开了制备庚环化合物和含有庚环化合物的组合物的工艺。本发明的庚环化合物可用于有效预防或治疗糖尿病和代谢综合征等疾病。
• ELIX, JOHN A.;VENABLES, DEBRA A.;BRAKO, LOIS, AUSTRAL. J. CHEM., 43,(1990) N1, C. 1953-1959
  作者：ELIX, JOHN A.、VENABLES, DEBRA A.、BRAKO, LOIS

  DOI：——

  日期：——
• US8158623B2
  申请人：——

  公开号：US8158623B2

  公开（公告）日：2012-04-17