Securinin | 1071758-20-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚里西啶
• 英文名称: Securinin
• 英文别名: Virosecurinin；Virosecurinine；14-oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-9,11-dien-13-one
• CAS: 1071758-20-7
• 化学式: C₁₃H₁₅NO₂
• mdl: MFCD00063360
• 分子量: 217.268
• InChiKey: SWZMSZQQJRKFBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.615
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 potassium carbonate 作用下， 以 水 为溶剂， 反应 0.5h， 生成 Securinin 、 Phyllochrysin
  参考文献：
  名称：

  由半月板内酯非对映选择性合成阿洛斯可林宁和病毒阿洛斯可林宁。

  摘要：

  据报道，一种新的，通用的合成Securinega生物碱的途径。使用乙烯基类曼尼希反应作为关键转化，从（+）-menisdaurilide开始，以7个步骤和40％的产率完成了Allosecurinine的首次合成。类似地，已经从（-）-半月桂脲内酯合成了四氢阿糖嘌呤。

  DOI：

  10.1021/jo801470u

文献信息

• Myeloid differentiation inducing agents
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US10300049B2

  公开（公告）日：2019-05-28

  Myeloid differentiating agents can be used in the treatment of myeloid proliferative disorders.

  骨髓分化剂可用于治疗骨髓增生性疾病。
• MYELOID DIFFERENTIATION INDUCING AGENTS
  申请人：Case Western Reserve University

  公开号：US20140018383A1

  公开（公告）日：2014-01-16

  Myeloid differentiating agents can be used in the treatment of myeloid proliferative disorders.
• SMALL MOLECULE SECURININE AND NORSECURININE ANALOGS AND THEIR USE IN CANCERS, INFLAMMATORY DISEASES AND INFECTIONS
  申请人：GUNDLURU Mahesha K.

  公开号：US20160229861A1

  公开（公告）日：2016-08-11

  The present invention relates to novel securinine and norsecurine analogs and their applicapility in treating cellular proliferative disorders.
• SMALL MOLECULE SECURININE AND NORSECURININE ANALOGS AND THEIR USE IN INHIBITING MYELOPEROXIDASE
  申请人：GUNDLURU Mahesh K.

  公开号：US20160250196A1

  公开（公告）日：2016-09-01

  The present invention relates to novel securinine and norsecurine analogs that have reduced or non-reduced gamma-delta bond. The present invention also provides for methods of using securinine analogs, comprising administering one or more of the analogs to a myeloperoxidase enzyme, such as an enzyme with or proximal to a cell. As set out herein, the securinine analogs directly bind to and inhibit myeloperoxidase (MPO) activity. Accordingly, contacting or administering the analogs to an MPO enzyme allows for inhibition of MPO activity.
• US9439894B2
  申请人：——

  公开号：US9439894B2

  公开（公告）日：2016-09-13