Meptazinol, (R)- | 34017-95-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: Meptazinol, (R)-
• 英文别名: 3-[(3R)-3-ethyl-1-methylazepan-3-yl]phenol
• CAS: 34017-95-3
• 化学式: C₁₅H₂₃NO
• 分子量: 233.35
• InChiKey: JLICHNCFTLFZJN-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compositions Comprising Enzyme-Cleavable Phenol-Modified Opioid Prodrugs and Inhibitors Thereof
  申请人：Jenkins Thomas E.

  公开号：US20110262360A1

  公开（公告）日：2011-10-27

  Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenol-modified opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the phenol-modified opioid prodrug so as to modify enzymatic cleavage of the phenol-modified opioid prodrug.

  提供了药物组合物及其使用方法，其中药物组合物包括一种苯酚修饰的阿片类前药，该前药提供酶控制释放苯酚类阿片类药物，并且包括与介导苯酚修饰的阿片类前药酶控制释放的酶相互作用的酶抑制剂，以调节苯酚修饰的阿片类前药的酶解。
• [EN] COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PHENOL-MODIFIED OPIOID PRODRUGS AND INHIBITORS THEREOF<br/>[FR] COMPOSITIONS COMPRENANT DES PROMÉDICAMENTS OPIACÉS MODIFIÉS PHÉNOL CLIVABLES PAR ENZYME ET LEURS INHIBITEURS
  申请人：PHARMACOFORE INC

  公开号：WO2011133151A1

  公开（公告）日：2011-10-27

  Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenol-modified opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the phenol-modified opioid prodrug so as to modify enzymatic cleavage of the phenol-modified opioid prodrug.

  提供了药物组合物及其使用方法，其中药物组合物包括一种酚修饰的阿片类前药，提供酶控释放酚类阿片类药物，以及一种酶抑制剂，与介导酚修饰的阿片类前药酶控释放的酶相互作用，以修改酶切割酚修饰的阿片类前药。
• Pharmaceutical Compositions with Attenuated Release of Phenolic Opioids
  申请人：Jenkins Thomas E.

  公开号：US20110281886A1

  公开（公告）日：2011-11-17

  Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.

  本发明提供了一种药物组合物及其使用方法，其中药物组合物包括一种酚类阿片类前药，该前药提供酶控释酚类阿片类药物，以及一种酶抑制剂，该酶抑制剂与介导酚类阿片类前药酶控释酚类阿片类药物的酶相互作用，以减弱前药的酶解。
• US8802681B2
  申请人：——

  公开号：US8802681B2

  公开（公告）日：2014-08-12
• US9534014B2
  申请人：——

  公开号：US9534014B2

  公开（公告）日：2017-01-03