3-Amino-1-(4-hydroxy-3-methoxy-phenyl)-1H,10H-4-oxa-9-thia-phenanthrene-2-carbonitrile | 135521-72-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 英文名称: 3-Amino-1-(4-hydroxy-3-methoxy-phenyl)-1H,10H-4-oxa-9-thia-phenanthrene-2-carbonitrile
• 英文别名: 4H,5H-[1]benzothiopyrano[4,3-b]pyran-3-carbonitrile, 2-amino-4-(4-hydroxy-3-methoxyphenyl)-；2-amino-4-(4-hydroxy-3-methoxyphenyl)-4,5-dihydrothiochromeno[4,3-b]pyran-3-carbonitrile
• CAS: 135521-72-1
• 化学式: C₂₀H₁₆N₂O₃S
• 分子量: 364.425
• InChiKey: VOFSESAGVNHABU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene]-thiochroman-4-one 、 丙二腈 在 哌啶 作用下， 以 乙醇 为溶剂， 以4.5%的产率得到3-Amino-1-(4-hydroxy-3-methoxy-phenyl)-1H,10H-4-oxa-9-thia-phenanthrene-2-carbonitrile
  参考文献：
  名称：

  The synthesis and antifungal activity of 2-amino-4-aryl-4H,5H-[1]benzothiopyrano[4,3-b]pyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-[1]benzothiopyrano[4,3-b]pyridine-3-carbonitriles

  摘要：

  This paper describes the synthesis of a series of 2-amino-4-aryl-4H, 5H-[1]benzothiopyrano[4,3-b]pyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-[1]benzothiopyrano[4,3-b]pyridine-3-carbonitriles. All of these products were studied for antifungal activity and many of these compounds displayed good activity against Cryptococcus neoformans. Torulopsis glabrata, and Trichosporon cutaneum.

  DOI：

  10.1016/0223-5234(91)90033-j

文献信息

• The synthesis and antifungal activity of 2-amino-4-aryl-4H,5H-[1]benzothiopyrano[4,3-b]pyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-[1]benzothiopyrano[4,3-b]pyridine-3-carbonitriles
  作者：TA Nakib、V Bezjak、S Rashid、B Fullam、MJ Meegan

  DOI：10.1016/0223-5234(91)90033-j

  日期：1991.3

  This paper describes the synthesis of a series of 2-amino-4-aryl-4H, 5H-[1]benzothiopyrano[4,3-b]pyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-[1]benzothiopyrano[4,3-b]pyridine-3-carbonitriles. All of these products were studied for antifungal activity and many of these compounds displayed good activity against Cryptococcus neoformans. Torulopsis glabrata, and Trichosporon cutaneum.