(i-bu)2SiF2 | 406-66-6

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (i-bu)2SiF2
• 英文别名: difluoro-diisobutyl-silane；Difluor-diisobutyl-silan；Difluorobis(2-methylpropyl)silane；difluoro-bis(2-methylpropyl)silane
• CAS: 406-66-6
• 化学式: C₈H₁₈F₂Si
• 分子量: 180.313
• InChiKey: JBFWEIYRGONWCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  (i-bu)2SiF2 在 sodium hydroxide 作用下， 生成 (i-bu)2Si(OH)2
  参考文献：
  名称：

  Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study

  摘要：

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.

  DOI：

  10.1038/modpathol.3880230
• 作为产物：
  描述：

  Isobutylmagnesium chloride 在 silicon tetrafluoride 作用下， 生成 (i-bu)2SiF2 、 (i-C4H9)3SiF
  参考文献：
  名称：

  Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study

  摘要：

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.

  DOI：

  10.1038/modpathol.3880230

文献信息

• Zur reaktionvon cyclotri- und cyclotri- und cyclotetrasilazanen mit silylfluoriden
  作者：Uwe Klingebiel、Detlev Enterling、Lutz Skoda、Anton Meller

  DOI：10.1016/s0022-328x(00)80856-6

  日期：1977.8

  lithium salts of hexamethylcyclotri- and octa-methylcyclotetrasilazanes with silicon tetrafluoride and organo-substituted silicon fluorides. Disubstituted compounds are obtained by the reaction of dilithium hexamethylcyclotrisilazane with silicon fluorides or by the reaction of lithium hexamethylcyclotrisilazane with silicon fluorides at higher temperature. Cyclosilazanes with bulky ligands react with

  氟硅烷基取代的环硅氮烷是通过用四氟化硅和有机取代的氟化硅处理六甲基环三硅烷基和八甲基环四硅氮烷的锂盐而形成的。通过六甲基环三硅氮烷二锂与氟化硅反应或通过六甲基环三硅氮烷锂与氟化硅在较高温度下反应获得双取代的化合物。第一步，具有大配体的环硅氮烷与丁基锂反应，消除丁烷，然后与LiF消除，进一步与氟化硅化合物反应，生成混合的取代环硅氮烷。通过氟硅烷基取代的环三硅氮烷与六甲基环三硅氮烷锂的反应可实现通过硅桥的环偶联。质量，1 H和报道了该化合物的19 F NMR谱。
• Eaborn, C., Journal of the Chemical Society
  作者：Eaborn, C.

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 39, page 120 - 121
  作者：

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 86, page 235 - 238
  作者：

  DOI：——

  日期：——
• Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study
  作者：Maureen J O'Sullivan、Michael Kyriakos、Xiaopei Zhu、Mark R Wick、Paul E Swanson、Louis P Dehner、Paul A Humphrey、John D Pfeifer

  DOI：10.1038/modpathol.3880230

  日期：2000.11

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.