cuprous chloride dihydrate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属盐
• 英文名称: cuprous chloride dihydrate
• 英文别名: copper chloride dihydrate；Chlorocopper;hydrate
• 化学式: Cl*Cu*2H₂O
• 分子量: 135.03
• InChiKey: HVKGITROGJEKIM-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.82
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cuprous chloride dihydrate 、 2-acetyl-8-amino-7-chloro-1,2,3,4-tetrahydroisoquinoline 在 二氧化硫 、 氯化镁 、 溶剂黄146 、 sodium nitrite 作用下， 以 盐酸 、 水 为溶剂， 生成 2-acetyl-8-chlorosulfonyl-7-chloro-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  Pharmaceutical compositions and methods of inhibiting phenylethanolamine

  摘要：

  制药组合物和使用7和/或8取代的1,2,3,4-四氢异喹啉化合物抑制苯乙醇胺N-甲基转移酶的方法。

  公开号：

  US03988339A1

文献信息

• Azabicyclohexanes
  申请人：American Cyanamid Company

  公开号：US04131611A1

  公开（公告）日：1978-12-26

  Substituted 3-azabicyclo[3.1.0]hexanes, acid addition salts, method of use and method of preparation are described. The compounds have anxiolytic and analgesic activity.

  取代的3-氮杂双环[3.1.0]己烷、酸加成盐、使用方法和制备方法被描述。这些化合物具有抗焦虑和镇痛活性。
• Method of treating depression using azabicyclohexanes
  申请人：American Cyanamid Company

  公开号：US04435419A1

  公开（公告）日：1984-03-06

  The present invention concerns certain novel substituted 3-azabicyclo[3.1.0]hexanes and a method of treating depression and stress in a warm-blooded animal, comprising the administration of substituted 3-azabicyclo[3.1.0]hexanes.

  本发明涉及某些新颖的取代3-氮杂双环[3.1.0]己烷，以及一种治疗温血动物抑郁和压力的方法，包括取代3-氮杂双环[3.1.0]己烷的给药。
• Benzenesulphonamide derivatives, preparation thereof and therapeutical uses thereof
  申请人：Synthelabo

  公开号：US06214882B1

  公开（公告）日：2001-04-10

  Benzenesulphonamide compounds of general formula (I), wherein R1 is a hydrogen or halogen atom such as chlorine or fluorine, or a straight or branched C1-4 alkyl or C1-4 alkoxy group, each of R2, R3 and R4, which are the same or different, is a hydrogen atom or a straight, branched or cyclic C1-4 alkyl group, and R1 is a hydrogen atom or a C1-2 alkyl, C1-2 fluoroalkyl or C1-2 perfluoroalkyl group, in the form of enantiomers, diastereoisomers or mixtures thereof, including racemic mixtures, as well as pharmaceutically acceptable acid addition salts thereof, are provided for therapeutical use.

  通用公式（I）的苯磺酰胺化合物，其中R1是氢或卤素原子，如氯或氟，或直链或支链C1-4烷基或C1-4烷氧基，R2、R3和R4各自是相同或不同的氢原子或直链、支链或环状C1-4烷基，R1是氢原子或C1-2烷基、C1-2氟烷基或C1-2全氟烷基，以对映体、非对映体异构体或它们的混合物形式提供，包括外消旋混合物，以及其药用可接受的酸盐，用于治疗目的。
• An X-ray absorption fine structure study of copper(I) chloride coordination structure in water up to 325°C
  作者：John L. Fulton、Markus M. Hoffmann、John G. Darab

  DOI：10.1016/s0009-2614(00)01110-6

  日期：2000.11

  X-ray absorption fine structure (XAFS) spectroscopy was used to measure the Cl- and H2O coordination structure about Cu1+ in water at temperatures up to 325 degreesC including the coordination numbers, symmetry, distances and the amount of bond disorder. The linear dichloro Cu1+ species, [CuCl2](-), is especially stable and it is predominant from 100 degreesC to 325 degreesC in the presence of excess Cl-. Even for solutions with 2.0 m NaCl, only the dichloro Cu1+ species is observed with no evidence of higher Cl- coordination. There is no evidence of hydration waters in the first-solvation shell of this dichloro-species. (C) 2000 Elsevier Science B.V. All rights reserved.
• Pharmaceutical compositions and methods of inhibiting phenylethanolamine
  申请人：SmithKline Corporation

  公开号：US03988339A1

  公开（公告）日：1976-10-26

  Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.

  制药组合物和使用7和/或8取代的1,2,3,4-四氢异喹啉化合物抑制苯乙醇胺N-甲基转移酶的方法。