fluorolead | 14986-72-2

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 后过渡金属盐
• 英文名称: fluorolead
• 英文别名: lead monofluoride radical；Fluoroplumbane
• CAS: 14986-72-2
• 化学式: FPb
• 分子量: 226.198
• InChiKey: WPQVKKFPOFIUFF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.04
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  fluorolead 、 20R,24S-epoxycycloartan-6α,16β,25-triol-3-one 6,16,25-triacetate 在 氟化氢吡啶 作用下， 生成 (2aR,3R,4S,5aS,5bS,7S,7aR,11aR,12aS)-3-((2R,5S)-5-(2-acetoxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-9,9-difluoro-2a,5a, 8,8-tetramethyltetradecahydro-1H, 12H-cyclopenta[a]cyclopropa[e]phenanthrene-4,7-diyl diacetate
  参考文献：
  名称：

  SERIES OF HALOGENATED TETRACYCLIC TRITERPENE DERIVATIVES AND THEIR PREPARATION AND APPLICATION

  摘要：

  本发明提供了一系列卤代四环三萜衍生物及其制备和应用。其通式如下：R1为卤素，R2为氢，卤素选自氟、氯、溴或碘；或R1和R2均为氟，R3为胺、醇、氨基酸、肽或磷酸，通过酰基连接到氧。通过药代动力学研究，这些衍生物在大鼠全血中相对稳定。单次口服给雄性和雌性大鼠后的绝对生物利用度分别为15.6％和28.4％。平均生物利用度为22％。与现有标准药物依那普利和沙库巴曲钠相比，这些衍生物在体内活性更好。同时，本发明还制备了四环三萜衍生物的亲水性前药。本发明的衍生物可用于制备心血管药物。

  公开号：

  US20220177511A1
• 作为产物：
  描述：

  lead 、 lead(II) fluoride 以 gas 为溶剂， 生成 fluorolead
  参考文献：
  名称：

  Laser fluorescence study of the Pb+F₂, Cl₂ reactions: Internal state distribution of the PbCl product and radiative lifetimes of PbF(A,B) and PbCl(A)

  摘要：

  The reactions of Pb atoms with molecular reagents F2 and Cl2 have been studied in a molecular beam apparatus by laser fluorescence detection of PbF and PbCl products. The experiments were performed in a beam-gas configuration under single-collision conditions. The PbCl product from Pb+Cl2 was observed in the vibrational levels v≤17 of the ground X1 electronic state. The PbCl product vibrational state distribution was derived; the average vibrational excitation was found to be 21% of the total available energy. For Pb+F2, PbF(X1) product was detected in only the v=0 and 1 vibrational levels, and the rovibrational state distribution could be characterized by a 300 K Boltzmann distribution. By modulating the Pb beam, it was concluded that this observed product was an artifact and did not arise from bimolecular gas-phase collisions. The radiative lifetimes of the PbF(A,B) and PbCl(A) states were also measured and were found to equal 4.9±0.3 μs, <10 ns, and 1.14±0.06 μs, respectively, averaged over the observed vibrational levels.

  DOI：

  10.1063/1.462189