2-(1-methylpiperidin-2-yl)acetic acid hydrochloride | 60979-27-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(1-methylpiperidin-2-yl)acetic acid hydrochloride
• 英文别名: (1-Methyl-piperidin-2-yl)-acetic acid hydrochloride；2-(1-methylpiperidin-2-yl)acetic acid;hydrochloride
• CAS: 60979-27-3
• 化学式: C₈H₁₅NO₂*ClH
• mdl: MFCD09759159
• 分子量: 193.674
• InChiKey: UNQGOLMAWGEVNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.92
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(1-methylpiperidin-2-yl)acetic acid hydrochloride 、 (2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methanamine 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 以47 %的产率得到2-(1-methylpiperidin-2-yl)-N-((2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methyl)acetamide
  参考文献：
  名称：

  AMIDE COMPOUNDS AS ACTIVATORS OF THE POTASSIUM CHANNELS KV7.2/KV7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS

  摘要：

  The present invention relates to compounds of formula (I) as defined in the specification capable of promoting the opening of Kv7.2/Kv7.3 potassium channels, a pharmaceutical composition comprising them, and their use as a drug, particularly in the treatment of disorders of the central nervous system (CNS), such as, for example, epilepsy and neurodegenerative disorders, and of the peripheral nervous system (PNS), such as, for example, chronic and neuropathic pain.

  公开号：

  WO2024121046A1

文献信息

• [EN] IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY<br/>[FR] LIPIDES IONISABLES POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：PREC NANOSYSTEMS INC

  公开号：WO2021000041A1

  公开（公告）日：2021-01-07

  The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) Wherein R1 includes an amino group. These compounds are particularly useful in the formulation and in vivo and ex vivo delivery of nucleic acid and protein therapeutics for preparing and implementing T cell transfection, gene editing, cancer therapies, cancer prophylactics, and in the preparation of vaccines.

  本文件描述了核心公式（I）的化合物或其药用可接受盐，其中R1包括氨基团。这些化合物在核酸和蛋白治疗剂的制剂、体内和体外递送中特别有用，用于制备和实施T细胞转染、基因编辑、癌症治疗、癌症预防以及疫苗的制备。
• [EN] IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY<br/>[FR] LIPIDES IONISABLES POUR ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：PREC NANOSYSTEMS INC

  公开号：WO2020252589A1

  公开（公告）日：2020-12-24

  The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) where R1 features an amine group, particularly useful in the formulation of lipid particles including nucleic acid therapeutic agents, or proteins, or both, and for delivery of nucleic acid and protein therapeutics to cells in vivo or ex vivo, including anticancer and vaccine applications.

  本文件描述了核心公式（I）的化合物或其药用可接受的盐，其中R1特征为胺基，特别适用于制备包括核酸治疗剂或蛋白质在内的脂质颗粒，并用于将核酸和蛋白质治疗剂递送到体内或体外的细胞中，包括抗癌和疫苗应用。
• Compounds useful as reversible inhibitors of cysteine proteases
  申请人：Boehringer Ingelheim Pharmaceuticals Inc.

  公开号：US20040063679A1

  公开（公告）日：2004-04-01

  Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds. 1

  本发明涉及一种新的cathepsin S、K、F、L和B可逆抑制化合物，其化学式为（Ia）和（Ib），其中R1、R2、R3、R4、R5、R6、R8、R9和X的定义如下。该化合物可用于治疗自身免疫和其他疾病。同时，本发明还公开了制备这种新化合物的方法。
• IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY
  申请人：Precision Nanosystems Inc

  公开号：EP3986866A1

  公开（公告）日：2022-04-27
• US4162322A
  申请人：——

  公开号：US4162322A

  公开（公告）日：1979-07-24