Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of a patient via the binding agent. Preferred binding agents comprise substrate-reactive and tissue-selective functional groups. Anti-adhesion compositions useful for the formation of such films are also disclosed.
本发明公开了可用于防止手术粘连的防粘连薄膜。这些薄膜包括基底材料(如
胶原蛋白)和异双官能防粘连结合剂,其中基底材料通过结合剂与患者体内的受体组织共价连接。优选的结合剂包括基底反应性和组织选择性官能团。此外,还公开了可用于形成此类薄膜的抗粘连组合物。