2'-hydroxyphenyl salicylate | 2553-11-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 2'-hydroxyphenyl salicylate
• 英文别名: 2-Hydroxy-phenyl-salicylat；Phenolsalicylat；(2-hydroxyphenyl) 2-hydroxybenzoate
• CAS: 2553-11-9
• 化学式: C₁₃H₁₀O₄
• 分子量: 230.22
• InChiKey: DPVGVPDHEWJQMW-UHFFFAOYSA-N

物化性质

• 熔点：
  80-81 °C
• 沸点：
  342.3±17.0 °C(Predicted)
• 密度：
  1.356±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2'-hydroxyphenyl salicylate 、 乙酸酐 、 吡啶 生成 (2-acetyloxyphenyl) 2-acetyloxybenzoate
  参考文献：
  名称：

  PATOLIA, R.;TRIVEDI, K. N., INDIAN J. CHEM., 1983, 22, N 5, 444-447

  摘要：

  DOI：
• 作为产物：
  描述：

  邻苯二酚 、 水杨酸乙酯 以 二苯醚 为溶剂， 反应 12.0h， 以48%的产率得到2'-hydroxyphenyl salicylate
  参考文献：
  名称：

  Patolia, Ravji J.; Trivedi, K. N., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 5, p. 444 - 447

  摘要：

  DOI：

文献信息

• Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof
  申请人：JAEHNE Gerhard

  公开号：US20110178134A1

  公开（公告）日：2011-07-21

  The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.

  本发明涉及具有所述意义的公式（I）的化合物，以及它们的生理相容性盐。所述化合物适用于例如作为抗肥胖药物和治疗心血管代谢综合征。
• Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof
  申请人：JAEHNE Gerhard

  公开号：US20110053947A1

  公开（公告）日：2011-03-03

  The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

  本发明涉及具有公式（I）的化合物，其中R和R'、A、D、E、G、L、p以及R1至R10具有所述含义，以及它们的生理相容性盐。所述化合物例如可作为抗肥胖药物使用。
• Novel aromatic fluoroglycoside derivatives, pharmaceuticals comprising said compounds and the use thereof
  申请人：FRICK Wendelin

  公开号：US20110059910A1

  公开（公告）日：2011-03-10

  The invention relates to substituted aromatic fluoroglycoside derivatives, and to the physiologically compatible salts and physiologically functional derivatives thereof. The invention also relates to methods of lowering blood sugar and the treatment of type I and type II diabetes.

  这项发明涉及取代芳香族氟糖苷衍生物，以及其生理兼容盐和生理功能衍生物。该发明还涉及降低血糖和治疗I型和II型糖尿病的方法。
• Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof
  申请人：Jaehne Gerhard

  公开号：US20110046105A1

  公开（公告）日：2011-02-24

  The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

  该发明涉及式(I)的化合物，其中基团R和R'、A、D、E、G、L、p以及R1到R10具有所述的含义，以及它们的生理兼容盐。所述化合物可作为抗肥胖药物，例如。
• Substituted imidazoline-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof
  申请人：Jaehne Gerhard

  公开号：US20110112097A1

  公开（公告）日：2011-05-12

  The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

  该发明涉及式(I)的化合物，其中基团R和R'、A、D、E、G、L、p以及R1到R10具有所述含义，以及它们的生理相容盐。所述化合物适用于作为抗肥胖药物。