salsalate | 1613372-40-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: salsalate
• 英文别名: [2-[2-[(2-Methylpropan-2-yl)oxycarbonyl]phenoxy]carbonylphenyl] pyridine-3-carboxylate；[2-[2-[(2-methylpropan-2-yl)oxycarbonyl]phenoxy]carbonylphenyl] pyridine-3-carboxylate
• CAS: 1613372-40-9
• 化学式: C₂₄H₂₁NO₆
• 分子量: 419.434
• InChiKey: XTEVXQLPJPPYIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  91.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  salsalate 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 生成 (R)-2-((2-(((1-(tert-butoxy)-4-((tert-butyldimethylsilyl)oxy)-3,3-dimethyl-1-oxobutan-2-yl)oxy)carbonyl)phenoxy)carbonyl)phenyl nicotinate
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES
  [FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU SYNDROME MÉTABOLIQUE ET DU DIABÈTE

  摘要：

  公开号：

  WO2014087307A3
• 作为产物：
  描述：

  双水杨酸酯 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 salsalate
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES
  [FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU SYNDROME MÉTABOLIQUE ET DU DIABÈTE

  摘要：

  公开号：

  WO2014087307A3

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME AND LIPID DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DU SYNDROME MÉTABOLIQUE ET DE TROUBLES LIPIDIQUES
  申请人：KANDULA MAHESH

  公开号：WO2014091465A2

  公开（公告）日：2014-06-19

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of metabolic syndrome and lipid disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes, hypertriglyceridemia, dyslipidemia, obesity and atherosclerosis.
• [EN] FATTY ACID CONJUGATES AND THEIR USES<br/>[FR] CONJUGUÉS D'ACIDES GRAS ET LEURS UTILISATIONS
  申请人：KANDULA MAHESH

  公开号：WO2014106805A2

  公开（公告）日：2014-07-10

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing metabolic syndrome, cancer, a metabolic disease, a neurodegenerative disease and insulin resistance and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, neuropathic pain, hypertriglyceridemia, hyperglycemia, hyperinsulinemia, metabolic syndrome, cancer, metabolic disease, neurodegenerative diseases and insulin resistance.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DU SYNDROME MÉTABOLIQUE ET DU DIABÈTE
  申请人：KANDULA MAHESH

  公开号：WO2014106804A2

  公开（公告）日：2014-07-10

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing metabolic syndrome and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, neuropathic pain, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU SYNDROME MÉTABOLIQUE ET DU DIABÈTE
  申请人：KANDULA MAHESH

  公开号：WO2014087307A3

  公开（公告）日：2014-07-31