Bis(5-morpholin-4-ylthiophen-2-yl)methanone | 373602-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: Bis(5-morpholin-4-ylthiophen-2-yl)methanone
• CAS: 373602-90-5
• 化学式: C₁₇H₂₀N₂O₃S₂
• 分子量: 364.489
• InChiKey: QDLVYOWSFPLQTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  98.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-(噻唑-2-基)吗啉 、 Bis(5-morpholin-4-ylthiophen-2-yl)methanone 在 正丁基锂 、 高氯酸 作用下， 以 1,4-二氧六环 、 正己烷 为溶剂， 反应 8.0h， 生成 4-[5-[Bis(5-morpholin-4-ylthiophen-2-yl)methylidene]-1,3-thiazol-2-ylidene]morpholin-4-ium;perchlorate
  参考文献：
  名称：

  Synthesis and Spectral Characterization of a New Class of Heterocyclic Analogues of Crystal Violet Dyes

  摘要：

  Deep purple: By the transformation of readily available N,N-disubstituted 2-aminothiophenes and 2-aminothiazoles into heterocyclic analogues of Crystal Violet, such as, tris(2-dimethylamino-5-thienyl)methinium prechlorate (cation shown), the series of dyes derived from these heterocyclic structural units as the important chromophoric component is significantly extended and a gap in the class of heteroanalogous triphenylmethane dyes has been closed.

  DOI：

  10.1002/1521-3773(20010817)40:16<3008::aid-anie3008>3.0.co;2-0
• 作为产物：
  描述：

  4-[3-(N,N-dimethylamino)-2-propene-1-thione]morpholine 在 三乙胺 作用下， 以 乙腈 为溶剂， 生成 Bis(5-morpholin-4-ylthiophen-2-yl)methanone
  参考文献：
  名称：

  Synthesis and Spectral Characterization of a New Class of Heterocyclic Analogues of Crystal Violet Dyes

  摘要：

  Deep purple: By the transformation of readily available N,N-disubstituted 2-aminothiophenes and 2-aminothiazoles into heterocyclic analogues of Crystal Violet, such as, tris(2-dimethylamino-5-thienyl)methinium prechlorate (cation shown), the series of dyes derived from these heterocyclic structural units as the important chromophoric component is significantly extended and a gap in the class of heteroanalogous triphenylmethane dyes has been closed.

  DOI：

  10.1002/1521-3773(20010817)40:16<3008::aid-anie3008>3.0.co;2-0

文献信息

• Synthesis and characterisation of N,N-disubstituted 2-amino-5-acylthiophenes and 2-amino-5-acylthiazoles
  作者：Antje Noack、Horst Hartmann

  DOI：10.1016/s0040-4020(02)00083-2

  日期：2002.3

  Starting from halomethyl-ketones 8 and N,N'-persubstituted thioacrylamides 7 or their 2-aza analogues 11 a series of N,N-disubstituted 2-amino-5-acylthiophenes 10 and 2-amino-5-acylthiazoles 12, respectively are available. By starting from 1,3-dichloroacetone and using the same thioacrylamide derivatives 7 and 11 N,N-disubstituted 2-amino-5-(chloroacetyl)thiophenes 13 and 2-amino-5-(chloroacetyl)thiazoles 14 as well as N,N'-persubstituted bis-(2-amino-5-thienyl)ketones 15, 2-amino-5-thienyl-(2-amino-5-thiazolyl)ketones 16, and bis-(2-amino-5-thiazolyl)ketones 17, respectively are available. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Synthesis and Spectral Characterization of a New Class of Heterocyclic Analogues of Crystal Violet Dyes
  作者：Antje Noack、Anke Schröder、Horst Hartmann

  DOI：10.1002/1521-3773(20010817)40:16<3008::aid-anie3008>3.0.co;2-0

  日期：2001.8.17

  Deep purple: By the transformation of readily available N,N-disubstituted 2-aminothiophenes and 2-aminothiazoles into heterocyclic analogues of Crystal Violet, such as, tris(2-dimethylamino-5-thienyl)methinium prechlorate (cation shown), the series of dyes derived from these heterocyclic structural units as the important chromophoric component is significantly extended and a gap in the class of heteroanalogous triphenylmethane dyes has been closed.