3-Phenyl-1-piperidinecarboxaldehyde | 19509-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-Phenyl-1-piperidinecarboxaldehyde
• 英文别名: 3-phenylpiperidine-1-carbaldehyde
• CAS: 19509-10-5
• 化学式: C₁₂H₁₅NO
• 分子量: 189.25
• InChiKey: NXLSFGZLUBTKCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• IMIDAZO[1,2-a]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES
  申请人：Bartolomé-Nebreda José Manuel

  公开号：US20120329792A1

  公开（公告）日：2012-12-27

  The present invention relates to novel imidazo[1,2-a]pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.

  本发明涉及新型咪唑并[1,2-a]吡嗪衍生物，其为磷酸二酯酶10（PDE10）的抑制剂，并且适用于治疗或预防涉及PDE10酶的神经、精神和代谢性疾病。该发明还涉及包含这类化合物的药物组合物，制备这类化合物和组合物的方法，以及利用这类化合物或药物组合物预防或治疗神经、精神和代谢性疾病和疾病。
• [EN] PIPERIDINE AND AZEPINE DERIVATIVES AS PROKINETICIN RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS PIPÉRIDINE ET AZÉPINE SERVANT DE MODULATEURS DU RÉCEPTEUR DE LA PROKINÉTICINE
  申请人：TAKEDA CAMBRIDGE LTD

  公开号：WO2015019103A1

  公开（公告）日：2015-02-12

  The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof (Formula (I)) in which m, X, R1, R2, R3 and R5 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供了式(I)的化合物及其药用盐（式(I)），其中m、X、R1、R2、R3和R5如规范中所定义，其制备方法，含有它们的药物组合物以及它们在治疗中的用途。
• QUATERNARY LACTAM COMPOUND AND PHARMACEUTICAL USE THEREOF
  申请人：Shanghai Meiyue Biotech Development Co., Ltd.

  公开号：EP3778588A1

  公开（公告）日：2021-02-17

  the invention discloses a quaternary lactam compound of formula (I), the preparation method and the pharmaceutical use thereof, and in particular the use in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders.

  本发明公开了一种式（I）的季铵内酰胺化合物、其制备方法和药物用途，特别是用于制造治疗和/或预防血栓或血栓栓塞疾病的药物。
• IMIDAZO [1, 2 -A]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2545055A1

  公开（公告）日：2013-01-16
• EP3030553A1
  申请人：——

  公开号：EP3030553A1

  公开（公告）日：2016-06-15