5-Methyl-2-isopropyl-Δ²-thiazolin | 18640-76-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 5-Methyl-2-isopropyl-Δ²-thiazolin
• 英文别名: 2-isopropyl-5-methyl-4,5-dihydro-thiazole；2-Isopropyl-5-methyl-4,5-dihydro-thiazol；Thiazole, 4,5-dihydro-2-isopropyl-5-methyl-；5-methyl-2-propan-2-yl-4,5-dihydro-1,3-thiazole
• CAS: 18640-76-1
• 化学式: C₇H₁₃NS
• 分子量: 143.253
• InChiKey: PFEWPDAXEFOJMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• INSULIN SENSITISERS AND METHODS OF TREATMENT
  申请人：Collier Gregory Royce

  公开号：US20110003740A1

  公开（公告）日：2011-01-06

  The present invention relates generally to the field of therapy. The invention particularly relates to insulin sensitisers and methods of regulating glucose homeostasis and to the therapeutic or prophylactic treatment of diseases and associated conditions, in which impaired glucose uptake due to insulin resistance is involved or implicated, such as diabetes, syndrome X, hyperglycaemia, vascular disease and kidney disease. The present invention further relates to compounds and agents and compositions thereof for use in the treatment methods.
• MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20190055220A1

  公开（公告）日：2019-02-21

  The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.