bis(5'-adenosyl) phosphate | 10003-91-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （5'->5'）-二核苷酸
• 英文名称: bis(5'-adenosyl) phosphate
• 英文别名: di(5'-adenosyl) phosphate；diadenosine monophosphate；adenosine-5'-diphosphate；ApA；adenylyl-(5'->5')-adenosine；Adenyl-8percent'-5')-adenosin；bis[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl] hydrogen phosphate
• CAS: 10003-91-5
• 化学式: C₂₀H₂₅N₁₀O₁₀P
• 分子量: 596.453
• InChiKey: BHANORHBGGAOIV-XPWFQUROSA-N

物化性质

• 沸点：
  1069.3±75.0 °C(Predicted)
• 密度：
  2.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  294
• 氢给体数：
  7
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  bis(5'-adenosyl) phosphate 、 (2R,4S,5R)-2-chloro-2-<17O>oxo-4,5-diphenyl-<1-18O>-1,3,2-dioxaphospholan 在 吡啶 、 <17O>phosphoryl chloride 、 氨 、 sodium 作用下， 生成 adenosine 5'-<γ-(S)-16O,17O,18O>phosphate
  参考文献：
  名称：

  手性[ 16 O，17 O，18 O]磷酸酯的合成

  摘要：

  描述了合成已知绝对构型的手性[ 16 O，17 O，18 O]磷酸单酯的立体定向路线。

  DOI：

  10.1039/p19810002317
• 作为产物：
  描述：

  腺苷 在 四氮唑 、 2-(N,N-diisopropylamino)-2-oxo-1,3,2-oxathiaphospholane 、 叔丁基过氧化氢 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 二甲基亚砜 、 癸烷 为溶剂， 反应 40.0h， 以65%的产率得到bis(5'-adenosyl) phosphate
  参考文献：
  名称：

  Solid-Phase Synthesis of Dinucleoside and Nucleoside-Carbohydrate Phosphodiesters and Thiophosphodiesters

  摘要：

  Unprotected nucleosides (ROH) were reacted with two polymers bound to N, N-diisopropylamino- 1,3,2-oxathiaphospholane in the presence of 1H-terazole. Oxidation with tertbutyl hydroperoxide or sulfurization with Beaucage's reagent, followed by the 1,3,2-oxathiaphospholane ring opening with unprotected nucleosides or carbohydrates (R'OH) in the presence of DBU, afforded nucleoside-(5'-5')-nucleoside or nucleoside- carbohydrate phosphodiester and thiophosphodiester derivatives through the elimination of polymer-bound ethylene episulfide. This strategy offers the advantages of facile isolation of final products and monosubstitution of unprotected nucleosides and carbohydrates.

  DOI：

  10.1021/jo0611115

文献信息

• MULTI-TARGET COMPOUND WITH ANTICOAGULATION AND ANTIPLATELET ACTIVITY, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：Shaanxi Micot Technology Limited Company

  公开号：EP3333177A1

  公开（公告）日：2018-06-13

  Provided is a multi-target compound with anticoagulation and platelet GPIIb/IIIa receptor antagonism. The formula of the multi-target compound is as follows: A-L-B-L'-C. A and B are binding sites with a thrombin, C is a binding site with a platelet GPIIb/IIIa receptor, L is a first linking group, and L' is a second linking group. Also provided are a preparation method for the compound and use of the compound. The compound has the effects on inhibiting human thrombin activity and a platelet GPIIb/IIIa receptor in vitro, and has the effects on antiplatelet aggregation in vitro/in vivo, and anticoagulation and antithrombosis in vivo.

  本文提供了一种具有抗凝和血小板 GPIIb/IIIa 受体拮抗作用的多靶点化合物。该多靶点化合物的分子式如下：A-L-B-L'-C。A和B是与凝血酶的结合位点，C是与血小板GPIIb/IIIa受体的结合位点，L是第一连接基团，L'是第二连接基团。此外，还提供了该化合物的制备方法和用途。该化合物在体外具有抑制人凝血酶活性和血小板 GPIIb/IIIa 受体的作用，在体外/体内具有抗血小板聚集的作用，在体内具有抗凝血和抗血栓形成的作用。
• MICROALGAE-DERIVED COMPOSITIONS FOR IMPROVING THE HEALTH AND APPEARANCE OF SKIN
  申请人：Solazyme, Inc.

  公开号：EP1986665A2

  公开（公告）日：2008-11-05
• METHOD FOR PRODUCING A LIQUID COMPOSITION
  申请人：The University of Liverpool

  公开号：EP3600245A1

  公开（公告）日：2020-02-05
• [EN] MICROALGAE-DERIVED COMPOSITIONS FOR IMPROVING THE HEALTH AND APPEARANCE OF SKIN<br/>[FR] COMPOSITIONS DÉRIVÉES DE MICROALGUES DESTINÉES À AMÉLIORER LA SANTÉ ET L'ASPECT DE LA PEAU
  申请人：SOLAZYME INC

  公开号：WO2007084769A2

  公开（公告）日：2007-07-26

  [EN] Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.
  [FR] L'invention concerne des compositions pour le soin de la peau à base de microalgues, ainsi que des procédés pour améliorer la santé et l'aspect de la peau. L'invention concerne également des méthodes d'utilisation de polysaccharides pour des applications telles que des produits topiques de soins personnels, des cosmétiques et des compositions destinées à réduire les rides. L'invention concerne par ailleurs de nouvelles compositions décolorées à base de microalgues qui sont utiles pour améliorer la santé et l'aspect de la peau. L'invention concerne en outre des particules polysaccharidiques insolubles à appliquer sur la peau.
• [EN] METHOD FOR PRODUCING A LIQUID COMPOSITION<br/>[FR] PROCÉDÉ DE PRODUCTION D'UNE COMPOSITION LIQUIDE
  申请人：UNIV LIVERPOOL

  公开号：WO2018178721A1

  公开（公告）日：2018-10-04

  A first aspect of the present invention provides a method of producing a liquid composition comprising stabilised particles of active species in oil by precipitating a solution of the active species in a non-solvent in the presence of one or more stabilisers, mixing the precipitate suspension with an oil and then removing the solvents. Further aspects of the present invention relate to liquid compositions produced by said method and methods of use of such liquid compositions.