3-[[3-(Dimethyl-{3-[tris-(3-hydroxy-propyl)-silanyl]-propyl}-silanyl)-propyl]-bis-(3-hydroxy-propyl)-silanyl]-propan-1-ol | 388592-95-8

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: 3-[[3-(Dimethyl-{3-[tris-(3-hydroxy-propyl)-silanyl]-propyl}-silanyl)-propyl]-bis-(3-hydroxy-propyl)-silanyl]-propan-1-ol
• 英文别名: 3-[3-[Dimethyl-[3-[tris(3-hydroxypropyl)silyl]propyl]silyl]propyl-bis(3-hydroxypropyl)silyl]propan-1-ol；3-[3-[dimethyl-[3-[tris(3-hydroxypropyl)silyl]propyl]silyl]propyl-bis(3-hydroxypropyl)silyl]propan-1-ol
• CAS: 388592-95-8
• 化学式: C₂₆H₆₀O₆Si₃
• 分子量: 553.015
• InChiKey: KWDHYOPVWNWMTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.67
• 重原子数：
  35
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  121
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-[[3-(Dimethyl-{3-[tris-(3-hydroxy-propyl)-silanyl]-propyl}-silanyl)-propyl]-bis-(3-hydroxy-propyl)-silanyl]-propan-1-ol 在 吡啶 、 甲基磺酰氯 、 sodium bromide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 bis[(3-bromopropylsilyl)propyl]dimethylsilane
  参考文献：
  名称：

  CARBOSILANE DENDRIMER AND AGGREGATABLE CARRIER OBTAINED USING SAID DENDRIMER FOR DRUG DELIVERY SYSTEM

  摘要：

  本发明的目的是提供一种可聚集载体材料用于药物传递系统及其形成的胶束。本发明提供了一种可聚集载体材料用于药物传递系统，其是通过利用硫醇基和烷基卤素之间的反应形成的。它是通过在水溶剂或水溶剂和有机溶剂混合溶剂中使用含有硅杂环和标记蛋白质（如绿色荧光蛋白）的碳硅树状分子形成的。由该材料组成的胶束可以在水溶剂中包含具有各种分子量和生物聚合物的化合物。

  公开号：

  US20170281782A1
• 作为产物：
  描述：

  在 溴代环己烷 、 双氧水 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 3-[[3-(Dimethyl-{3-[tris-(3-hydroxy-propyl)-silanyl]-propyl}-silanyl)-propyl]-bis-(3-hydroxy-propyl)-silanyl]-propan-1-ol
  参考文献：
  名称：

  CARBOSILANE DENDRIMER AND AGGREGATABLE CARRIER OBTAINED USING SAID DENDRIMER FOR DRUG DELIVERY SYSTEM

  摘要：

  本发明的目的是提供一种可聚集载体材料用于药物传递系统及其形成的胶束。本发明提供了一种可聚集载体材料用于药物传递系统，其是通过利用硫醇基和烷基卤素之间的反应形成的。它是通过在水溶剂或水溶剂和有机溶剂混合溶剂中使用含有硅杂环和标记蛋白质（如绿色荧光蛋白）的碳硅树状分子形成的。由该材料组成的胶束可以在水溶剂中包含具有各种分子量和生物聚合物的化合物。

  公开号：

  US20170281782A1

文献信息

• Systematic syntheses of influenza neuraminidase inhibitors: A series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties
  作者：Jun-Ichi Sakamoto、Tetsuo Koyama、Daisei Miyamoto、Sangchai Yingsakmongkon、Kazuya I.P.J. Hidari、Wipawee Jampangern、Takashi Suzuki、Yasuo Suzuki、Yasuaki Esumi、Takemichi Nakamura、Ken Hatano、Daiyo Terunuma、Koji Matsuoka

  DOI：10.1016/j.bmc.2009.06.036

  日期：2009.8

  and 12-functionalized dendrimers, and in linkage patterns, such as normal aliphatic linkage, ether- and amide-linkages. Biological evaluations of these glycodendrimers showed that all of the ether- and amide-elongated compounds had inhibitory potencies for the influenza sialidases in the mM range, while compounds having normal aliphatic linkage did not have any activities except for a 12-functionalized

  为了开发新型流感唾液酸酶抑制剂，我们构建了糖簇库，该糖簇由十二种具有硫糖苷键的唾液酸化树枝状大分子组成，可抵抗唾液酸酶的水解。通过唾液酸经乙酰基修饰的糖苷配基在糖苷配基末端改性的硫代唾液酸苷与十二种具有溴化末端的碳硅烷树状大分子在脱乙酰基条件下的缩合反应合成了这些唾液酸树枝状酯，并进行了暂时的重新保护以进行纯化。通过酯交换作用和随后的皂化作用来除去对糖类树状聚合物的所有保护，从而以良好的产率提供相应的水溶性糖类树状聚合物。为了研究结构与活动的关系，树枝状大分子支架，其中糖部分的数目不同，例如3-，4-，6-和12-官能化树枝状大分子，并且在连接方式上不同，例如正常的脂族连接，醚-和酰胺-连接。这些糖类树状大分子的生物学评估表明，所有醚和酰胺延长的化合物都对mN范围的唾液酸流感病毒具有抑制作用，而具有正常脂族键的化合物除12-官能化化合物外没有任何活性。
• Synthetic assembly of trisaccharide moieties of globotriaosyl ceramide using carbosilane dendrimers as cores. A new type of functional glyco-material
  作者：Koji Matsuoka、Mikiko Terabatake、Yasuaki Esumi、Daiyo Terunuma、Hiroyoshi Kuzuhara

  DOI：10.1016/s0040-4039(99)01632-9

  日期：1999.10

  As a novel type of artificial receptor for Vero toxins, three pairs of carbosilane dendrimers uniformly carrying 12, 6, and 3 units of trisaccharide moieties of globotriaosyl ceramide were prepared through formation of the sulfide linkages in liquid NH3, which revealed unexpected differences among their biological responses. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Synthesis and Influenza Virus Inhibitory Activities of Carbosilane Dendrimers Peripherally Functionalized with Hemagglutinin-Binding Peptide
  作者：Ken Hatano、Teruhiko Matsubara、Yosuke Muramatsu、Masakazu Ezure、Tetsuo Koyama、Koji Matsuoka、Ryunosuke Kuriyama、Haruka Kori、Toshinori Sato

  DOI：10.1021/jm5007676

  日期：2014.10.23

  A series of carbosilane dendrimers uniformly functionalized with hemagglutinin (HA) binding peptide (sialic acid-mimic peptide, Ala-Arg-Leu-Pro-Arg) was systematically synthesized, and their anti-influenza virus activity was evaluated. The carbosilane-based peptide dendrimers, unlike sialylated dendrimers, cannot be digested by virus neuraminidases. The peptide dendrimers exhibited intriguing biological activities depending on the form of their core frame, with a dumbbell-type peptide dendrimer showing particularly strong inhibitory activities against two human influenza viruses, A/PR/8/34 (H1N1) and A/Aichi/2/68 (H3N2). The IC50 values of the dumbbell-type peptide dendrimer for both strains were 0.60 mu M, the highest activity among the HA-binding peptide derivatives. The results suggest that a dumbbell-shaped carbosilane dendrimer is the most suitable core scaffold for HA-binding peptide dendrimers.
• Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors
  作者：Jun-Ichi Sakamoto、Tetsuo Koyama、Daisei Miyamoto、Sangchai Yingsakmongkon、Kazuya I.P.J. Hidari、Wipawee Jampangern、Takashi Suzuki、Yasuo Suzuki、Yasuaki Esumi、Ken Hatano、Daiyo Terunuma、Koji Matsuoka

  DOI：10.1016/j.bmcl.2006.10.085

  日期：2007.2

  An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with alpha-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases. (c) 2006 Elsevier Ltd. All rights reserved.
• CARBOSILANE DENDRIMER AND AGGREGATABLE CARRIER OBTAINED USING SAID DENDRIMER FOR DRUG DELIVERY SYSTEM
  申请人：Quarrymen & Co. Inc.

  公开号：US20170281782A1

  公开（公告）日：2017-10-05

  The object of the present invention is to provide an aggregatable carrier material for drug delivery system and a micelle formed thereof. The present invention provides an aggregatable carrier material for drug delivery system, which is formed by utilizing the reaction between thiol group and alkyl halide. It is formed by using carbosilane dendrimers containing silole and labeled proteins such as green fluorescent protein in aqueous solvent or in mixed solvent of the aqueous solvent and organic solvent. The micelle composed of the material may incorporate compounds having a variety of molecular weight and biopolymers in the aqueous solvent.

  本发明的目的是提供一种可聚集载体材料用于药物传递系统及其形成的胶束。本发明提供了一种可聚集载体材料用于药物传递系统，其是通过利用硫醇基和烷基卤素之间的反应形成的。它是通过在水溶剂或水溶剂和有机溶剂混合溶剂中使用含有硅杂环和标记蛋白质（如绿色荧光蛋白）的碳硅树状分子形成的。由该材料组成的胶束可以在水溶剂中包含具有各种分子量和生物聚合物的化合物。