[4-(5-aminomethyl-2-fluorophenyl)piperidine-1-yl][7-fluoro-1-(2-methoxyethyl)-4-trifluoromethoxy-1H-indol-3-yl]methanone benzenesulfonate. | 1208977-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [4-(5-aminomethyl-2-fluorophenyl)piperidine-1-yl][7-fluoro-1-(2-methoxyethyl)-4-trifluoromethoxy-1H-indol-3-yl]methanone benzenesulfonate.
• 英文别名: [4-(5-aminomethyl-2-fluorophenyl)piperidine-1-yl][7-fluoro-1-(2-methoxyethyl)-4-trifluoromethoxy-1H-indol-3-yl]methanone benzenesulfonate；[4-[5-(aminomethyl)-2-fluorophenyl]piperidin-1-yl]-[7-fluoro-1-(2-methoxyethyl)-4-(trifluoromethoxy)indol-3-yl]methanone;benzenesulfonic acid
• CAS: 1208977-02-9
• 化学式: C₆H₆O₃S*C₂₅H₂₆F₅N₃O₃
• 分子量: 669.67
• InChiKey: RMOHYGOUQMWVIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.88
• 重原子数：
  46
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  [4-(5-aminomethyl-2-fluorophenyl)piperidine-1-yl][7-fluoro-1-(2-methoxyethyl)-4-trifluoromethoxy-1H-indol-3-yl]methanone 、 苯磺酸 以 乙腈 为溶剂， 以86.7%的产率得到[4-(5-aminomethyl-2-fluorophenyl)piperidine-1-yl][7-fluoro-1-(2-methoxyethyl)-4-trifluoromethoxy-1H-indol-3-yl]methanone benzenesulfonate.
  参考文献：
  名称：

  [EN] [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-ETHYL)-4-TRIFLUOROMETHOXY-1H-INDOL-3-YL]-METHANONE AS AN INHIBITOR OF MAST CELL TRYPTASE
  [FR] [4-(5-AMINOMÉTHYL-2-FLUORO-PHÉNYL)-PIPÉRIDIN-1-YL]-[7-FLUORO-1-(2-MÉTHOXY-ÉTHYL)-4-TRIFLUOROMÉTHOXY-1H-INDOL-3-YL]-MÉTHANONE EN TANT QU'INHIBITEUR DE LA TRYPTASE DE MASTOCYTES

  摘要：

  公开号：

  WO2010022196A3

文献信息

• [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-ETHYL)-4-TRIFLUOROMETHOXY-1H-INDOL-3-YL]-METHANONE AS AN INHIBITOR OF MAST CELL TRYPTASE
  申请人：CHOI-SLEDESKI Yong Mi

  公开号：US20110201647A1

  公开（公告）日：2011-08-18

  The present invention is directed to an indole benzylamine compound of formula I: useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient of a therapeutically effective amount of the compound, and to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier.

  本发明涉及一种式为I的吲哚苄胺化合物：用作抑制组胺酶的药物。此外，本发明还涉及使用该化合物治疗患有或受到需要通过抑制组胺酶改善生理状况的患者，包括向患者施用该化合物的治疗有效量，以及包括式I化合物的药物组合物，其中该化合物的药物有效量和药物可接受载体。
• [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-flouro-1-(2-methoxy-ethyl)-4-trifluorom as an inhibitor of mast cell tryptase
  申请人：Sanofi

  公开号：US08217178B2

  公开（公告）日：2012-07-10

  The present invention is directed to an indole benzylamine compound of formula I: useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient of a therapeutically effective amount of the compound, and to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier.

  本发明涉及一种式I的吲哚苄胺化合物: 作为抑制酪氨酸酶的抑制剂。此外，本发明还涉及使用该化合物治疗患有或受到需要通过抑制酪氨酸酶改善生理状况的患者，包括向患者施用该化合物的治疗有效量，以及包含式I的该化合物的药物组合物和药用载体。
• Method and intermediates for the preparation of 2,2,2-trifluoro-N-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride
  申请人：Choi-Sledeski Yong Mi

  公开号：US08497379B2

  公开（公告）日：2013-07-30

  The present invention is directed to a method for the preparation of 2,2,2-trifluoro-n-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride of the formula: and reaction intermediates used in the method.

  本发明涉及一种制备2,2,2-三氟-N-(4-氟-3-吡啶-4-基苄基)乙酰胺盐酸盐的方法，以及在该方法中使用的反应中间体。
• [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-ETHYL)-4TRIFLUOROMETHOXY-1H-INDOL-3-YL]METHANONE AS AN INHIBITOR OF MAST CELL TRYPTASE
  申请人：SANOFI

  公开号：EP2367812B1

  公开（公告）日：2015-09-16
• US8217178B2
  申请人：——

  公开号：US8217178B2

  公开（公告）日：2012-07-10