tert-Butyl 4-(1-aminopropyl)piperidine-1-carboxylate | 1290046-62-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-Butyl 4-(1-aminopropyl)piperidine-1-carboxylate
• 英文别名: tert-butyl 4-(1-aminopropyl)piperidine-1-carboxylate
• CAS: 1290046-62-6
• 化学式: C₁₃H₂₆N₂O₂
• 分子量: 242.36
• InChiKey: PMAWBAFHGHQTEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 1,3,4-OXADIAZOLONE COMPOUND AND MEDICINE
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP3882239A1

  公开（公告）日：2021-09-22

  The purpose of the present invention is to provide a compound having PIM inhibitory activity. Examples of the present invention include 1,3,4-oxadiazolone compounds represented by the following formula [1], and pharmaceutically acceptable salts, and solvates thereof. The compounds of the present invention have PIM inhibitory activity. In addition, since the compounds of the present invention have PIM inhibitory activity, the compounds of the present invention are useful as therapeutic agents for systemic lupus erythematosus, lupus nephritis, etc.

  本发明的目的是提供一种具有 PIM 抑制活性的化合物。 本发明的实例包括下式[1]代表的 1，3，4-噁二唑酮化合物及其药学上可接受的盐和溶液。 本发明的化合物具有 PIM 抑制活性。此外，由于本发明的化合物具有 PIM 抑制活性，因此本发明的化合物可用作系统性红斑狼疮、狼疮肾炎等的治疗剂。
• 1,3,4-OXADIAZOLONE COMPOUND AND PHARMACEUTICAL
  申请人：NIPPON SHINYAKU CO., LTD.

  公开号：US20220024921A1

  公开（公告）日：2022-01-27

  The purpose of the present invention is to provide a compound having PIM inhibitory activity. Examples of the present invention include 1,3,4-oxadiazolone compounds represented by the following formula [1], and pharmaceutically acceptable salts thereof, and solvates thereof. The compounds of the present invention have PIM inhibitory activity. In addition, since the compounds of the present invention have PIM inhibitory activity, the compounds of the present invention are useful as therapeutic agents for systemic lupus erythematosus, lupus nephritis, etc.