4-(aminomethyl)-1-(1,3-dioxolan-2-ylmethyl)-4-piperidinol | 278805-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(aminomethyl)-1-(1,3-dioxolan-2-ylmethyl)-4-piperidinol
• 英文别名: 4-(aminomethyl)-1-(1,3-dioxolan-2-ylmethyl)piperidin-4-ol
• CAS: 278805-33-7
• 化学式: C₁₀H₂₀N₂O₃
• 分子量: 216.28
• InChiKey: CLZQNNVZKPINPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
  申请人：——

  公开号：US20030181456A1

  公开（公告）日：2003-09-25

  The present invention of compounds of formula (I) 1 a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, —R 1 —R 2 — is a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C 1-6 alkyl or hydroxy; R 3 is hydrogen or halo; R 4 is hydrogen or C 1-6 alkyl; R 5 is hydrogen or C 1-6 alkyl; L is C 3-6 cycloalkyl, oxoC 5-6 cycloalkyl, C 2-6 alkenyl, or L is a radical of formula -Alk-R 6 —, Alk-X—R 7 , -Alk-Y—C(═O)—R 9 , or -Alk-Y—C(═O)—NR 11 R 12 wherein each Alk is C 1-12 alkanediyl; and R 6 is hydrogen, amino, cyano, C 1-6 alkylsulfonylamino, C 3-6 cycloalkyl, oxoC 5-6 cycloalkyl, aryl or a heterocyclic ringsystem; R 7 is hydrogen, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 3-6 cycloalkyl, aryl or a heterocyclic ringsystem; X is O, S, SO 2 or NR 8 ; said R 8 being hydrogen or C 1-6 alkyl; R 9 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyloxy, hydroxy or aryl; Y is a direct bond or NR 10 ; said R 10 being hydrogen, or C 1-6 alkyl; R 11 and R 12 each independently are hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, or R 11 and R 12 combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4 -morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating or preventing gastrointestinal disorders.

  本发明涉及一种化合物，其化学式为（I）1a立体化学异构体形式，其N-氧化物形式或药学上可接受的酸盐形式，其中-R1-R2-是一个化学式的二价基团，在所述的二价基团中，一个或两个氢原子可以被C1-6烷基或羟基取代；R3是氢或卤素；R4是氢或C1-6烷基；R5是氢或C1-6烷基；L是C3-6环烷基，氧代C5-6环烷基，C2-6烯基，或L是化学式-Alk-R6-，Alk-X-R7，-Alk-Y-C(═O)-R9，或-Alk-Y-C(═O)-NR11R12的基团，其中每个Alk是C1-12烷基二亚基；R6是氢，氨基，氰基，C1-6烷基磺酰氨基，C3-6环烷基，氧代C5-6环烷基，芳基或杂环环系统；R7是氢，C1-6烷基，羟基C1-6烷基，C3-6环烷基，芳基或杂环环系统；X是O，S，SO2或NR8；其中R8是氢或C1-6烷基；R9是氢，C1-6烷基，C3-6环烷基，C1-6烷氧基，羟基或芳基；Y是直接键或NR10；其中R10是氢或C1-6烷基；R11和R12各自独立地是氢，C1-6烷基，C3-6环烷基，或R11和R12与氮原子结合可以形成一个可选取代的吡咯烷基，哌啶基，哌嗪基或4-吗啉基环。本发明还公开了制备所述产品的方法，包含所述产品的制剂以及其作为药物的用途，特别是用于治疗或预防胃肠道疾病。
• 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES FOR TREATING GASTROINTESTINAL DISORDERS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1140915B1

  公开（公告）日：2005-06-15
• US6544997B1
  申请人：——

  公开号：US6544997B1

  公开（公告）日：2003-04-08
• US7205410B2
  申请人：——

  公开号：US7205410B2

  公开（公告）日：2007-04-17