1-(2-phenylethyl)-4-(ethyl-1,3,4-oxadiazolyl)-4-(N-phenylpropionamido)piperidine | 120070-67-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(2-phenylethyl)-4-(ethyl-1,3,4-oxadiazolyl)-4-(N-phenylpropionamido)piperidine
• 英文别名: N-[4-(5-ethyl-1,3,4-oxadiazol-2-yl)-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide
• CAS: 120070-67-9
• 化学式: C₂₆H₃₂N₄O₂
• 分子量: 432.566
• InChiKey: PBASLODBWAMEGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  62.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  丙酰氯 生成 1-(2-phenylethyl)-4-(ethyl-1,3,4-oxadiazolyl)-4-(N-phenylpropionamido)piperidine
  参考文献：
  名称：

  LIN, BOR-SHENG;KUDZMA, L. V.

  摘要：

  DOI：

文献信息

• 4-heteropentacyclic-4-[N-(phenyl)amino] piperidine derivatives and
  申请人：The BOC Group, Inc.

  公开号：US04791120A1

  公开（公告）日：1988-12-13

  Compounds are disclosed of the formula ##STR1## where R.sup.1 is an unsubstituted or substituted heterocyclic ring system; R.sup.2 is an unsubstituted or substituted phenyl; R.sup.3 is a lower alkyl or lower alkoxy, and L is selected from a wide variety of groups.

  本发明揭示了以下式子的化合物：##STR1## 其中R.sup.1是未取代或取代的杂环环系；R.sup.2是未取代或取代的苯基；R.sup.3是低碳基或低烷氧基，且L被选择自多种基团。
• Methods of preparing 4-heteropentacyclic-4-(N-phenyl)amido) piperidine
  申请人：BOC, Inc.

  公开号：US04831192A1

  公开（公告）日：1989-05-16

  Compounds are disclosed of the formula ##STR1## Where R.sup.1 is an unsubstituted or substituted heterocyclic ring system; R.sup.2 is an unsubstituted or substituted phenyl; R.sup.3 is a lower alkyl or lower alkoxy, and L is selected from a wide variety of groups.

  公开了化合物的式子为##STR1##其中，R.sup.1是未取代或取代的杂环环系；R.sup.2是未取代或取代的苯基；R.sup.3是低碳基或低烷氧基，而L是从各种各样的基团中选择的。
• 4-heteropentacyclic-4-(N-(phenyl)amido) piperidine derivatives and
  申请人：BOC, Inc.

  公开号：US04871749A1

  公开（公告）日：1989-10-03

  Compounds are disclosed of the formula ##STR1## wherein R.sup.1 is an unsubstituted or substituted herterocyclic ring system; R.sup.2 is an unsubstituted or substituted phenyl; R.sup.3 is a lower alkyl or lower alkoxy, and L is selected from a wide variety of groups.

  公开了化合物的结构式##STR1##其中R.sup.1是未取代或取代的杂环环系；R.sup.2是未取代或取代的苯基；R.sup.3是较低的烷基或烷氧基，L是从各种各样的基团中选择的。
• 4-Heteropentacyclic-4- N-(phenyl)amido piperidine compounds
  申请人：Ohmeda Pharmaceutical Products Division Inc.

  公开号：EP0328830A1

  公开（公告）日：1989-08-23

  A compound of the formula and/or a pharmaceutically acceptable acid addition salt thereof, in which formula: R1 is an unsaturated heterocyclic ring of 5 cyclic member atoms, including 1 to 4 nitrogen atoms, and 0 to 1 sulphur or oxygen atoms, said heterocyclic ring being unsubstituted or substituted wherein the or each substituent is selected from lower alkyl, lower alkoxy and lower alkoxy lower alkyl groups; R2 is a substituted or unsustituted phenyl group in which the or each substituent is a halogen atom; R3 is a lower alkyl or a lower alkoxy lower alkyl group; and L is a lower alkyl group; a lower alkoxy group; a thienyl lower alkyl group; a lower alkoxy lower alkyl group; a thiazolyl lower alkyl group, unsubstituted, or substituted in the 4-position (of the thiazolylmoiety) with a lower alkyl group; a (4,5-di-hydro-5-oxo-1 H-tetrazol-1-yl) lower alkyl group, unsubstituted, or substituted in the 4-position (of the tetrazolyl moiety) with a lower alkyl group; a pyrazolyl lower alkyl group; a pyridinyl lower alkyl group; an oxophenyl lower alkyl group; a 2,4-(1 H,3H)-pyridinedionyl group, disusbstituted in the 3-position with lower alkyl groups; or a phenyl lower alkyl group, unsubstituted or substituted (in the phenyl moiety) with at least one substituent selected from lower alkyl groups; lower alkoxy groups, halgenated lower alkyl groups, and halogen atoms, has analgesic and anaesthetic properties and may be used in analagesic and anaesthetic compositions.

  式化合物 和/或其药学上可接受的酸加成盐，其中式 R1 是由 5 个环状成员原子组成的不饱和杂环，包括 1 至 4 个氮原子和 0 至 1 个硫或氧原子，所述杂环是未取代或取代的，其中或每个取代基选自低级烷基、低级烷氧基和低级烷氧基低级烷基； R2 是取代或未取代的苯基，其中或每个取代基是卤素原子； R3 是低级烷基或低级烷氧基低级烷基；以及 L 是低级烷基；低级烷氧基；噻吩基低级烷基；低级烷氧基低级烷基；未取代的噻唑基低级烷基，或在(噻唑基)4 位被低级烷基取代的噻唑基低级烷基；未被取代的(4,5-二氢-5-氧代-1 H-四唑-1-基)低级烷基，或在(四唑基)的 4 位被低级烷基取代的(4,5-二氢-5-氧代-1 H-四唑-1-基) 或苯基低级烷基，未被取代或（在苯基中）被至少一个选自低级烷基、低级烷氧基、卤代低级烷基和卤素原子的取代基取代，具有镇痛和麻醉特性，可用于镇痛和麻醉组合物中。
• JPH01213278A
  申请人：——

  公开号：JPH01213278A

  公开（公告）日：1989-08-28