N-methanesulfinylpiperidine | 13455-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-methanesulfinylpiperidine
• 英文别名: Methylsulfinylpiperidid；1-methanesulfinyl-piperidine；Methansulfinsaeure-piperidid；1-Methylsulfinylpiperidine
• CAS: 13455-94-2
• 化学式: C₆H₁₃NOS
• 分子量: 147.241
• InChiKey: ULHFBGVOMWWGOP-UHFFFAOYSA-N

物化性质

• 沸点：
  40-43 °C(Press: 0.01 Torr)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  39.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methanesulfinylpiperidine 在 oxonium 作用下， 以 phosphate buffer 、 乙腈 为溶剂， 生成 哌啶 、 甲烷磺酸
  参考文献：
  名称：

  烷基和芳基亚磺酰胺的水解速率：一般酸催化的证据

  摘要：

  亚磺酰胺在对映选择性合成中很重要，它是蛋白质的罕见翻译后修饰，也是酰胺键的等排物。关于脂族亚磺酰胺的水解速率或水解机理知之甚少。在这封信中，我们证明了亚磺酰胺主要通过磷酸盐缓冲液的非特异性酸/碱催化水解，但是通过改变缓冲液浓度，可以通过非线性最小二乘法确定一定范围的亚磺酰胺在水中的水解速率。回归。

  DOI：

  10.1016/j.tetlet.2007.08.081
• 作为产物：
  描述：

  methyl piperidinosulfenate 生成 N-methanesulfinylpiperidine
  参考文献：
  名称：

  Wenschuh, Eberhard; Kuehne, Ulrich; Mikolajczyk, Marian, Zeitschrift fur Chemie, 1981, vol. 21, # 6, p. 217 - 218

  摘要：

  DOI：

文献信息

• Transsulfinamidation of Sulfinamides with Amines
  作者：Saori Tsuzuki、Taichi Kano

  DOI：10.1021/acs.orglett.3c02534

  日期：2023.9.15

  Metal- and additive-free transsulfinamidation of N-unsubstituted sulfinamides and N-pivaloyl-protected sulfinamides with various amines is reported. With this method, both N-monosubstituted and N,N-disubstituted sulfinamides were obtained in good yields simply by heating. Preliminary experiments also indicate that alcohols can be used as nucleophiles instead of amines and can provide sulfinate esters

  报道了N-未取代的亚磺酰胺和N-新戊酰保护的亚磺酰胺与各种胺的无金属和添加剂的转亚磺酰胺化。通过该方法，仅通过加热即可以良好的收率获得N-单取代和N , N-二取代亚磺酰胺。初步实验还表明，醇可以代替胺作为亲核试剂，并且可以提供亚磺酸酯。
• OPTICAL RECORDING MEDIUM, METAL COMPLEX COMPOUND AND ORGANIC DYE COMPOUND
  申请人：Mitsubishi Kagaku Media Corporation, Ltd.

  公开号：EP1864822A1

  公开（公告）日：2007-12-12

  Problem: To provide an optical recording medium having a recording layer improved in light stability that is capable of writing and reading of high-density optical information by a short-wavelength laser beam. Means for Solving the Problems: There is provided an optical recording medium with a recoding layer comprising an organic dye compound, wherein the recording layer contains a metal complex compound composed of a pyridone azo compound represented by the following the general formulas [I] to [III] and a divalent ion of metal coordinated to it such as nickel, cobalt, iron, zinc, copper, manganese and the like, wherein the pyridone azo compound contains a 6-hydroxy-2-pyridone structure as a coupling component and isoxazole, 1,2,4-triazole or pyrazole structure as a diazo component. (In the general formulas [I] to [III], R1 to R10 each is independently a hydrogen atom or monovalent functional group.)

  问题：提供一种光学记录介质，其记录层的光稳定性得到改善，能够通过短波长激光束写入和读取高密度光学信息。 解决问题的方法：本发明提供了一种具有由有机染料化合物组成的重编码层的光学记录介质，其中记录层含有一种金属络合物，该金属络合物由以下通式[I]至[III]表示的吡啶酮偶氮化合物和与之配位的二价金属离子如镍组成、其中吡啶酮偶氮化合物包含作为偶联组分的 6-羟基-2-吡啶酮结构和作为重氮组分的异噁唑、1,2,4-三唑或吡唑结构。 (在通式[I]至[III]中，R1 至 R10 各自独立地为氢原子或单价官能团）。
• OPTICAL RECORDING MEDIUM, OPTICAL RECORDING MATERIAL AND METAL COMPLEX COMPOUND
  申请人：Mitsubishi Kagaku Media Co., Ltd.

  公开号：EP1903561A1

  公开（公告）日：2008-03-26

  [Problem]: An optical recording medium having a capability of recording and/or reading high density optical information using a short wavelength laser light is provided. [Means to Address the Problem]: The optical recording medium has a capability of recording and/or reading high density optical information using a short wavelength laser light having a wavelength of 350 nm to 530 nm. The optical recording medium has a recording layer containing a metal complex compound and formed on a substrate. The metal complex compound is composed of a cyclic β-diketone azo compound represented by the general formula (I) or general formula (II) and a divalent metal ion coordinated to the cyclic β-diketone azo compound.

  问题提供一种利用短波长激光记录和/或读取高密度光学信息的光学记录介质。 [解决问题的方法］该光学记录介质能够使用波长为 350 纳米至 530 纳米的短波长激光记录和/或读取高密度光学信息。该光学记录介质有一个记录层，其中含有一种金属复合物，并形成在基底上。金属络合物由通式（I）或通式（II）表示的环β-二酮偶氮化合物和与环β-二酮偶氮化合物配位的二价金属离子组成。
• PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR
  申请人：Incyte Holdings Corporation

  公开号：EP3838903A1

  公开（公告）日：2021-06-23

  The present invention provides the use of the following compounds for the preparation of a medicament for use in the treatment of a viral disease.

  本发明提供了以下化合物用于制备治疗病毒性疾病的药物。
• Mikolajczyk, Marian; Kielbasinski, Piotr; Bujnicki, Bogdan, Phosphorus and Sulfur and the Related Elements, 1985, vol. 25, p. 85 - 90
  作者：Mikolajczyk, Marian、Kielbasinski, Piotr、Bujnicki, Bogdan、Wenschuh, Eberhard、Kuehne, Ulrich

  DOI：——

  日期：——