trityl perchlorate | 16721-97-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: trityl perchlorate
• 英文别名: triphenylmethyl perchlorate
• CAS: 16721-97-4
• 化学式: C₁₉H₁₅ClO₄
• 分子量: 342.779
• InChiKey: FUCBQMFTYFQCOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  trityl perchlorate 在 吡啶 、 2,4,6-三甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 5.75h， 生成 4-O-acetyl-1,2-O-<1-(exo-cyano)ethylidene>-6-deoxy-3-O-trityl-α-D-glucopyranose
  参考文献：
  名称：

  高压对糖基化反应立体定向的影响

  摘要：

  在1.4 GPa的压力和室温下，糖的1,2-O-氰基亚乙基衍生物对三苯甲基醚的糖基化作用以及适当单体在二氯甲烷中的缩聚反应具有绝对立体定向性，从而产生1,2-反式糖苷键，尽管在环境压力下，所研究的反应显示出较低的立体特异性。高压对糖苷键形成的立体特异性的影响被解释为是由于随着压力的增加，单环糖基阳离子和双环酰基氧鎓阳离子之间的平衡向后者转移。

  DOI：

  10.1016/0008-6215(87)80133-7
• 作为产物：
  描述：

  三苯基氯甲烷 在 silver perchlorate 作用下， 以 二氯甲烷-D2 为溶剂， 反应 22.0h， 生成 trityl perchlorate
  参考文献：
  名称：

  Homogeneous Catalysis. Mechanisms of the Catalytic Mukaiyama Aldol and Sakurai Allylation Reactions

  摘要：

  The mechanisms of a number of Mukaiyama aldol and Sakurai allylation reactions catalyzed by the Lewis acids [Ti(Cp)(2)(OTf)(2)], Ph(3)COTf, and Ph(3)CClO(4) have been investigated. It is found that hydrolysis of the Lewis acid by trace amounts of water in the solvent can lead to the formation of acid. The acid then reacts with the silyl enol ether or allylic silane to generate Me(3)SiOTf or Me(3)SiClO(4), both of which are powerful catalysts for these reactions. Dehydration of the solvent or addition of a hindered base to quench the acid does not necessarily prevent the formation of these silyl catalysts. In the case of the [Ti(Cp)(2)(OTf)(2)] Lewis acid, Me(3)SiOTf is generated as a consequence of the mechanism, and it is shown that all of the catalysis proceeds by the Me(3)SiOTf species and that [Ti(Cp)(2)(OTf)(2)] acts only as an initiator for the production of Me(3)SiOTf. For the case of the presumed Ph(3)COTf catalyst, the Mukaiyama aldol reaction proceeds exclusively by the Me(3)SiOTf catalyst and Ph(3)COTf is neither an initiator nor a catalyst. It generates Me(3)SiOTf by hydrolysis. It is shown that the rate and stereoselectivity of Me(3)SiOTf catalysis depend on the concentration of triflate ions. The rate slows and the selectivity switches with an increase in triflate concentration. The rate of Sakurai catalysis of allylsilane with an acetal using Ph(3)CClO(4) can be quantitatively accounted for by invoking only Me(3)SiClO(4) catalysis. The Me(3)SiClO(4) can be generated by hydrolysis, but when this is suppressed, Me(3)SiClO(4) can be formed by allylation of Ph(3)CClO(4). It is suggested that many of the reported catalysts may only be agents for the production of the real catalysts, namely, Me(3)SiX species. The characteristics of Lewis acids which may obviate the intrusion of Me(3)SiX catalysis are outlined.

  DOI：

  10.1021/ja00121a015
• 作为试剂：
  描述：

  9,10-dihydro-10-methylacridine 在 2,2'-联吡啶 、 trityl perchlorate 、 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 乙腈 为溶剂， 反应 22.0h， 生成 9-(benzoyl(cyclohexyl)carbamoyl)-10-methylacridinium perchlorate
  参考文献：
  名称：

  新型氧化Ugi反应合成高活性，可见光，酰亚胺啶有机光催化剂

  摘要：

  提出了一种新设计的基于a啶基的有机光催化剂，该催化剂在C9位带有一个酰亚胺基团。为了实现这些空前的结构，开发了一种基于新的直接氧化的Ugi型反应的合成策略，该反应在C9未取代的cri啶酮的苄基位置上进行。酰亚胺单元的引入显着增强了光催化活性，从而可以在不同的氧化性和还原性可见光催化反应中进行有效转化。

  DOI：

  10.1002/chem.201802830

文献信息

• A Practical Silicon-Free Strategy for Differentiation of Hydroxy Groups in Arabinofuranose Derivatives
  作者：Polina Abronina、Nikita Podvalnyy、Sergey Sedinkin、Ksenia Fedina、Alexander Zinin、Alexander Chizhov、Vladimir Torgov、Leonid Kononov

  DOI：10.1055/s-0031-1290752

  日期：2012.4

  arabinofuranose derivatives, which is required for the preparation of building blocks useful for the synthesis of nucleoside analogues and oligosaccharide fragments of mycobacterial arabinogalactan and lipoarabinomannan, was achieved by using 3,5-di-O-benzoyl-1,2-O-benzylidene-β-d-arabinofuranose or 3-O-(chloroacetyl)-β-d-arabinofuranose 1,2,5-orthobenzoate, both readily accessible from inexpensive methyl α-d-arabinofuranoside

  致力于纪念已故的莱昂五世·巴尼诺夫斯基教授 抽象 通过使用3,5可实现阿拉伯呋喃糖衍生物中3,5-二醇系统和2-羟基的有效区分，这对于制备可用于合成分枝杆菌阿拉伯半乳聚糖和lipoarabinomannan的核苷类似物和寡糖片段的结构单元是必需的。二- ø -苯甲酰基-1,2- ø -亚苄基-β- d -arabinofuranose或3- ø - （氯乙酰基）-β- d -arabinofuranose 1,2,5- orthobenzoate，既容易从廉价的甲基α-访问d-阿拉伯呋喃糖苷通过相应的糖基溴化物。在这种新颖的策略中，完全避免了使用昂贵的有机硅保护基，这一特点使其可以按比例放大。 通过使用3,5可实现阿拉伯呋喃糖衍生物中3,5-二醇系统和2-羟基的有效区分，这对于制备可用于合成分枝杆菌阿拉伯半乳聚糖和lipoarabinomannan的核苷类似物和寡糖片段的结构单元是必需的。二-
• [EN] N-SUBSTITUTED MANNOSAMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE<br/>[FR] DÉRIVÉS N-SUBSTITUÉS DE MANNOSAMINE, PROCÉDÉ POUR LEUR PRÉPARATION ET LEUR UTILISATION
  申请人：GLYCOM AS

  公开号：WO2012140576A1

  公开（公告）日：2012-10-18

  A compound of the formula (I) wherein R1 is a group removable by hydrogenolysis,and wherein R2 is OH or R2 is -NHR3 wherein R3 is a group removable by hydrogenolysis. The compound can be made from fructose by a Heyns-rearrangement. The compound can be used then to make - free D-mannosamine or its salts, - D-mannosamine building blocks and mannosamine containing oligo- or polysaccharides, - N-acetyl-D-mannosamine and its hydrates and solvates, - neuraminic acid derivatives and, - viral neuraminidase inhibitors.

  公式(I)的化合物，其中R1是可通过氢解去除的基团，且其中R2是OH或R2是-NHR3，其中R3是可通过氢解去除的基团。该化合物可以通过Heyns重排从果糖制备。然后，该化合物可用于制备无游离α-D-甘露糖胺或其盐，α-D-甘露糖胺构建块和含甘露糖胺的寡糖或多糖，N-乙酰-D-甘露糖胺及其水合物和溶剂化物，神经氨酸衍生物以及病毒神经氨酸酶抑制剂。
• [EN] MANUFACTURE OF LACTO-N-TETRAOSE<br/>[FR] FABRICATION DE LACTO-N-TÉTRAOSE
  申请人：GLYCOM AS

  公开号：WO2012155916A1

  公开（公告）日：2012-11-22

  The present invention relates to the synthesis of the tetrasaccharide of formula (I) and novel intermediates used in the synthesis.

  本发明涉及公式（I）的四糖的合成以及合成中使用的新型中间体。
• [EN] MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES<br/>[FR] MATÉRIAUX POUR DISPOSITIFS ÉLECTROLUMINESCENTS ORGANIQUES
  申请人：MERCK PATENT GMBH

  公开号：WO2018065357A1

  公开（公告）日：2018-04-12

  The present invention relates to compounds of formula (1). The compounds are suitable for use in electronic devices, in particular organic electroluminescent devices, comprising these compounds. In some embodiments, the compounds are used as matrix materials for phosphorescent or fluorescent emitters as well as a hole-blocking or electron-transport materials.

  本发明涉及式(1)的化合物。这些化合物适用于电子设备，特别是含有这些化合物的有机电致发光设备。在某些实施方式中，这些化合物用作磷光或荧光发射器的基体材料以及空穴阻挡或电子传输材料。
• MASKED CARBOXYLATE NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE
  申请人：Jandeleit Bernd

  公开号：US20090069419A1

  公开（公告）日：2009-03-12

  Masked carboxylate neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.

  掩蔽羧酸新戊磺酰酯丙戊酸酯前药，包含此类前药的药物组合物，以及使用此类前药和组合物治疗疾病的方法被披露。具体来说，披露了表现出增强口服生物利用度的丙戊酸酯前药和使用丙戊酸酯前药治疗神经退行性疾病、精神疾病、情绪障碍、焦虑障碍、躯体形式障碍、运动障碍、物质滥用障碍、暴饮暴食障碍、皮层扩散性抑郁相关障碍、耳鸣、睡眠障碍、多发性硬化症和疼痛的方法。