| 1005339-09-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• CAS: 1005339-09-2
• 化学式: C₉H₁₈OSi
• 分子量: 170.327
• InChiKey: BCVADGLIRUYMDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  、 苯乙醛 在 bis(η3-allyl-μ-chloropalladium(II)) 六甲基二锡 、 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以71%的产率得到(2RS,7RS)-(Z)-2-benzyl-7-methyl-2,3,6,7-tetrahydrooxepine
  参考文献：
  名称：

  Regulation of Cyclization for the Stereoselective Synthesis of Substituted Tetrahydrofurans and Tetrahydrooxepines

  摘要：

  Dramatic solvent effect is observed during the cyclization of 1. Synthesis of 2 is achieved from the reaction of I with a hexamethylditin-catalyzed palladium complex followed by aldehydes in the presence of TMSOTf in THF, whereas 3 is formed in CH2Cl2. The method described herein is successful with various substrates 1 in good yields and high levels of diastereoselectivity.

  DOI：

  10.1021/ol7026569

文献信息

• Regulation of Cyclization for the Stereoselective Synthesis of Substituted Tetrahydrofurans and Tetrahydrooxepines
  作者：Sang-Hoon Kim、Seung-Ju Oh、Pil-Su Ho、Sin-Cheol Kang、Kyung-Jin O、Chan-Mo Yu

  DOI：10.1021/ol7026569

  日期：2008.1.1

  Dramatic solvent effect is observed during the cyclization of 1. Synthesis of 2 is achieved from the reaction of I with a hexamethylditin-catalyzed palladium complex followed by aldehydes in the presence of TMSOTf in THF, whereas 3 is formed in CH2Cl2. The method described herein is successful with various substrates 1 in good yields and high levels of diastereoselectivity.