S-p-tolyl 2-methylprop-2-enethioate | 893445-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚酯
• 英文名称: S-p-tolyl 2-methylprop-2-enethioate
• 英文别名: S-(4-methylphenyl) 2-methylprop-2-enethioate
• CAS: 893445-23-3
• 化学式: C₁₁H₁₂OS
• 分子量: 192.282
• InChiKey: HQLUGQPSNCQCOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  S-p-tolyl 2-methylprop-2-enethioate 、 4-甲苯硫酚 在 air 作用下， 以 二甲基亚砜 为溶剂， 反应 12.0h， 以77%的产率得到S-(p-tolyl) 2-hydroxy-2-methyl-3-(p-tolylthio)propanethioate
  参考文献：
  名称：

  DMSO-Mediated Difunctionalization of Electron-Deficient Olefins to Access β-Hydroxysulfides with High Chemoselectivity

  摘要：

  报道了一种通过DMSO介导的高度化学选择性合成β-羟基硫醚的新颖便捷方法。这种环保友好的反应适用于广泛的底物，并通过自由基过程以高选择性将所需的β-羟基硫醚以中等至良好的产率提供。此外，几种药用和生物活性分子也适用于这种反应条件，以良好的产率提供目标产物。

  DOI：

  10.1055/s-0041-1737341

文献信息

• Reactions of α,β-Unsaturated Thioesters with Platinum(0):  Implication of a Dual Mechanism Leading to the Formation of Acyl Platinum
  作者：Yasunori Minami、Tomohiro Kato、Hitoshi Kuniyasu、Jun Terao、Nobuaki Kambe

  DOI：10.1021/om050834w

  日期：2006.6.1

  The moderate reactivity of the alpha,beta-unsaturated thioester (ArS) C(O) C(A)-C(B)(H) toward Pt(PPh3)(2)( C2H4) has been used to extract thermodynamic and kinetic information pertaining to the oxidative addition of alpha,beta-unsaturated acid halide derivatives to low-valent transition-metal complexes. The results indicate acyl platinum product complexes can form by direct C-S bond cleavage or by attack of coordinated Pt(PPh3)(2) on the beta-carbon.
• RESPONSIVE MICROGEL AND METHODS RELATED THERETO
  申请人：SUPRATEK PHARMA, INC.

  公开号：EP1478403A1

  公开（公告）日：2004-11-24
• [EN] RESPONSIVE MICROGEL AND METHODS RELATED THERETO<br/>[FR] MICROGEL SENSIBLE ET SES PROCEDES ASSOCIES
  申请人：SUPRATEK PHARMA INC

  公开号：WO2003063909A1

  公开（公告）日：2003-08-07

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of 'dangling chains' and wherein the 'dangling chains' of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substanially linear and sustained release of the therapeutic entity under physiological conditions.