2-(5-nitro-thiophen-2-yl)-thiazole-4-carbaldehyde | 31898-37-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-(5-nitro-thiophen-2-yl)-thiazole-4-carbaldehyde
• 英文别名: 2-(5-Nitro-2-thienyl)-4-formyl-thiazol；4-Thiazolecarboxaldehyde, 2-(5-nitro-2-thienyl)-；2-(5-nitrothiophen-2-yl)-1,3-thiazole-4-carbaldehyde
• CAS: 31898-37-0
• 化学式: C₈H₄N₂O₃S₂
• 分子量: 240.263
• InChiKey: NKUIGIUMTOAMIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  132
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(5-nitro-thiophen-2-yl)-thiazole-4-carbaldehyde 以80%的产率得到
  参考文献：
  名称：

  VERGE J. P.; ROFFEY P., J. MED. CHEM. , 1975, 18, NO 8, 794-797

  摘要：

  DOI：
• 作为产物：
  描述：

  5-nitro-thiophene-2-carbothioic acid amide 在 盐酸 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 生成 2-(5-nitro-thiophen-2-yl)-thiazole-4-carbaldehyde
  参考文献：
  名称：

  Antiprotozoal thiazoles. 2-(5-Nitro-2-thienyl)thiazoles

  摘要：

  A series of 2-(5-nitro-2-thienyl)thiazoles and their vinylogs having substituted methylamine side chains has been prepared by halogen displacement on the corresponding 4-chloromethylthiazole. Of these, 4-morpholinomethyl-2-(5-nitro-2-thienyl)thiazole showed moderate activity against Trypanosoma cruzi and Trypanosoma rhodesiense in mice. This compound formed the lead for a series of analogous thiazole-4-carboxaldehyde hydrazones. Some of the latter were found active in curing murine Tryp. cruzi and Tryp. rhodesiense infections and to have low acute toxicity. A comparison with known active compounds is given and some structural features necessary for activity are discussed.

  DOI：

  10.1021/jm00242a007

文献信息

• Antiprotozoal thiazoles. 2-(5-Nitro-2-thienyl)thiazoles
  作者：John P. Verge、Patrick Roffey

  DOI：10.1021/jm00242a007

  日期：1975.8

  A series of 2-(5-nitro-2-thienyl)thiazoles and their vinylogs having substituted methylamine side chains has been prepared by halogen displacement on the corresponding 4-chloromethylthiazole. Of these, 4-morpholinomethyl-2-(5-nitro-2-thienyl)thiazole showed moderate activity against Trypanosoma cruzi and Trypanosoma rhodesiense in mice. This compound formed the lead for a series of analogous thiazole-4-carboxaldehyde hydrazones. Some of the latter were found active in curing murine Tryp. cruzi and Tryp. rhodesiense infections and to have low acute toxicity. A comparison with known active compounds is given and some structural features necessary for activity are discussed.
• VERGE J. P.; ROFFEY P., J. MED. CHEM. <JMCM-AR>, 1975, 18, NO 8, 794-797
  作者：VERGE J. P.、 ROFFEY P.

  DOI：——

  日期：——