Di-isobutylphosphinsaeurechlorid | 1118-29-2

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: Di-isobutylphosphinsaeurechlorid
• 英文别名: Diisobutylphosphinyl chloride；1-[chloro(2-methylpropyl)phosphoryl]-2-methylpropane
• CAS: 1118-29-2
• 化学式: C₈H₁₈ClOP
• 分子量: 196.657
• InChiKey: FKTWHPRHZDOJRC-UHFFFAOYSA-N

物化性质

• 沸点：
  110-110.5 °C(Press: 2 Torr)
• 密度：
  1.0216 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Di-isobutylphosphinsaeurechlorid 在 氨 、 水 作用下， 以 氯仿 为溶剂， 生成 bis(2-methylpropyl)phosphinic acid
  参考文献：
  名称：

  Mukhacheva,O.A.; Razumov,A.I., Journal of general chemistry of the USSR, 1962, vol. 32, p. 2654 - 2656

  摘要：

  DOI：
• 作为产物：
  描述：

  bis(2-methylpropyl)phosphinic acid 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 0.5h， 以94.4%的产率得到Di-isobutylphosphinsaeurechlorid
  参考文献：
  名称：

  Ramage, Robert; Atrash, Butrus; Hopton, David, Journal of the Chemical Society. Perkin transactions I, 1985, p. 1217 - 1226

  摘要：

  DOI：

文献信息

• beta-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING beta-DIHYDROFURAN DERIVING COMPOUND OR beta-TETRAHYDROFURAN DERIVING COMPOUND, beta-GLYCOSIDE COMPOUND, METHOD FOR PRODUCING beta GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF
  申请人：Iriyama Yusuke

  公开号：US20120322995A1

  公开（公告）日：2012-12-20

  The invention provides a process for producing a β-dihydrofuran derivative represented by formula (1) or a β-tetrahydrofuran derivative represented by formula (4), characterized in that the process includes causing a dialkyl dicarbonate, a diaralkyl dicarbonate, or a halide to act on a diol compound represented by formula (2) or (3). The invention also provides a process for producing 4′-ethynyl-2′,3′-didehydro-3′-deoxythymidine or an analog thereof, the process including glycosylation and deprotection.

  该发明提供了一种生产由式（1）表示的β-二氢呋喃衍生物或由式（4）表示的β-四氢呋喃衍生物的过程，其特征在于该过程包括使二烷基二碳酸酯、二芳基二碳酸酯或卤化物作用于由式（2）或（3）表示的二醇化合物。该发明还提供了一种生产4'-乙炔基-2',3'-二去氢-3'-脱氧胸苷或其类似物的过程，包括糖基化和去保护。
• Phosphine oxides having a physiological cooling effect
  申请人：Wilkinson Sword Limited

  公开号：US04070496A1

  公开（公告）日：1978-01-24

  Compounds and compositions are disclosed having a physiological cooling action on the skin. The compositions contain as the active ingredient certain phosphine oxides. The compositions disclosed include toilet and cosmetic preparations, e.g. toilet water, after-shave lotions, soaps, cosmetic creams and lotions, dentifrices and cleansing tissues, and tobacco and tobacco preparations.

  揭示了对皮肤具有生理降温作用的化合物和组合物。这些组合物包含某些膦氧化物作为活性成分。所披露的组合物包括香水和化妆品制剂，例如香水、剃须水、肥皂、化妆品霜和乳液、牙膏和清洁面纸，以及烟草和烟草制品。
• COMPOSITONS FOR TRP-M8 BINDING AND RADIORECEPTOR METHODS THEREWITH
  申请人：——

  公开号：US20040161751A1

  公开（公告）日：2004-08-19

  One embodiment of the invention is a composition that comprises a radioactive 32 P or 33 P phosphine oxide molecule. The said composition is designed to bind to the transient potential receptor-M8 (TRP-M8) receptor of cells. The radioactive 32 P or 33 P phosphine oxide ligand may be used for radioreceptor binding studies and for diagnostic studies of cancerous tissues. The TRP-M8 receptor is selectively expressed in malignant tissues such as prostate cancer cells. Affinity of the 32 P or 33 P phosphine oxide ligand for the TRP-M8 receptor confers selectivity and specificity in delivering lethal radiation to the diseased cells.

  本发明的一个实施例是一种组合物，其中包括一种放射性32P或33P膦氧化物分子。该组合物被设计为结合细胞的瞬时电位受体-M8（TRP-M8）受体。放射性32P或33P膦氧化物配体可用于放射受体结合研究和癌组织的诊断研究。TRP-M8受体在恶性组织（如前列腺癌细胞）中有选择性表达。32P或33P膦氧化物配体对TRP-M8受体的亲和力赋予了选择性和特异性，可向患病细胞输送致命辐射。
• Compositions for TRP-M8 binding and radioreceptor methods therewith
  申请人：Wei Edward T.

  公开号：US06893626B2

  公开（公告）日：2005-05-17

  One embodiment of the invention is a composition that comprises a radioactive 32 P or 33 P phosphine oxide molecule. The said composition is designed to bind to the transient potential receptor-M8 (TRP-M8) receptor of cells. The radioactive 32 P or 33 P phosphine oxide ligand may be used for radioreceptor binding studies and for diagnostic studies of cancerous tissues. The TRP-M8 receptor is selectively expressed in malignant tissues such as prostate cancer cells. Affinity of the 32 P or 33 P phosphine oxide ligand for the TRP-M8 receptor confers selectively and specificity in delivering lethal radiation to the diseased cells.

  本发明的一种实施例是一种组合物，其包含一种放射性32P或33P膦氧化物分子。该组合物被设计用于结合细胞的瞬时电位受体-M8（TRP-M8）受体。放射性32P或33P膦氧化物配体可用于放射性受体结合研究和癌组织诊断研究。TRP-M8受体选择性地表达在恶性组织中，如前列腺癌细胞。32P或33P膦氧化物配体对TRP-M8受体的亲和力赋予了选择性和特异性，可将致命辐射传递给患病细胞。
• B-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING B-DIHYDROFURAN DERIVING COMPOUND OR B-TETRAHYDROFURAN DERIVING COMPOUND, B -GLYCOSIDE COMPOUND, METHOD FOR PRODUCING B-GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2537839A1

  公开（公告）日：2012-12-26

  The invention provides a process for producing a β-dihydrofuran derivative represented by formula (1) or a β-tetrahydrofuran derivative represented by formula (4), characterized in that the process includes causing a dialkyl dicarbonate, a diaralkyl dicarbonate, or a halide to act on a diol compound represented by formula (2) or (3). The invention also provides a process for producing 4'-ethynyl-2',3'-didehydro-3'-deoxythymidine or an analog thereof, the process including glycosylation and deprotection.

  本发明提供了一种生产由式(1)表示的β-二氢呋喃衍生物或由式(4)表示的β-四氢呋喃衍生物的工艺，其特征在于该工艺包括使二烷基二碳酸酯、二烷基二碳酸酯或卤化物作用于由式(2)或(3)表示的二元醇化合物。本发明还提供了一种生产 4'-乙炔基-2',3'-二脱氢-3'-脱氧胸苷或其类似物的工艺，该工艺包括糖基化和脱保护。