1-Methyl-vic-triazolo<4,5-b>pyridin | 4372-68-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 1-Methyl-vic-triazolo<4,5-b>pyridin
• 英文别名: 3-Methyltriazolo<4,5-b>pyridin；1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridine；1-Methyl-1H-[1,2,3]triazolo[4,5-b]pyridine；1-methyltriazolo[4,5-b]pyridine
• CAS: 4372-68-3
• 化学式: C₆H₆N₄
• 分子量: 134.14
• InChiKey: OAQXUEQIZVXLLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• New coupling agents for peptide synthesis
  申请人：Carpino A. Louis

  公开号：US20070112196A1

  公开（公告）日：2007-05-17

  The present invention is directed to compounds of the formula (I) and (II) or salts thereof or N-oxides and their use in peptide synthesis.

  本发明涉及式（I）和（II）化合物或其盐或N-氧化物以及它们在肽合成中的应用。
• NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS
  申请人：Carpino Louis A.

  公开号：US20120277428A1

  公开（公告）日：2012-11-01

  The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.

  本发明涉及公式化合物：或其盐或N-氧化物及其在肽合成中的应用。
• GDF-8 Inhibitors
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20140107073A1

  公开（公告）日：2014-04-17

  Described are GCF-8 inhibitors of the formula (I), and pharmaceutically acceptable salts thereof, wherein n, R 1 , R 2 , R 5 , R 6 , X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue.

  本文描述了式（I）的GCF-8抑制剂及其药学上可接受的盐，其中n、R1、R2、R5、R6、X和Z在此定义。还提供了包含这些化合物的制药组合物。这些化合物和组合物在抑制细胞中的GDF-8和治疗患有疾病或障碍的患者的方法中有用，其中患者从增加肌肉组织的质量或力量中获得治疗上的益处。
• PRMT5 INHIBITORS AND USES THEREOF
  申请人：Epizyme, Inc.

  公开号：US20150191432A1

  公开（公告）日：2015-07-09

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

  本文描述了公式（I）的化合物，其药学上可接受的盐和制药组合物。本发明的化合物对于抑制PRMT5活性是有用的。还描述了使用这些化合物治疗PRMT5介导的疾病的方法。
• PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF
  申请人：EPIZYME, INC.

  公开号：US20150344433A1

  公开（公告）日：2015-12-03

  Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

  本文描述了公式（A）的化合物，其药学上可接受的盐和药物组合物。本发明的化合物可用于抑制PRMT5活性。还描述了使用这些化合物治疗PRMT5介导的疾病的方法。