Methyl (1-methylpiperidin-3-yl)carbamate | 183483-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Methyl (1-methylpiperidin-3-yl)carbamate
• 英文别名: methyl N-(1-methylpiperidin-3-yl)carbamate
• CAS: 183483-10-5
• 化学式: C₈H₁₆N₂O₂
• 分子量: 172.22
• InChiKey: HYQYNBCUHXUWGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP3774760A1

  公开（公告）日：2021-02-17
• [EN] PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER<br/>[FR] DÉRIVÉS DE PLADIÉNOLIDE EN TANT QU'AGENTS CIBLANT UN COMPLEXE D'ÉPISSAGE POUR LE TRAITEMENT DU CANCER
  申请人：COOK ANDREW

  公开号：WO2019200100A1

  公开（公告）日：2019-10-17

  The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.