4-(4-fluoro-3-methylphenyl)-4-hydroxypiperidine | 233261-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(4-fluoro-3-methylphenyl)-4-hydroxypiperidine
• 英文别名: 4-(4-fluoro-3-methylphenyl)piperidin-4-ol；4-(4-Fluoro-3-methylphenyl)-4-piperidinol
• CAS: 233261-73-9
• 化学式: C₁₂H₁₆FNO
• 分子量: 209.264
• InChiKey: MNUZBWLIPUZYOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20160031908A1

  公开（公告）日：2016-02-04

  Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

  揭示了新颖的化合物以及治疗与异常白细胞召集和/或激活相关的疾病的方法。该方法包括向需要的受试者施用代表的化合物的有效量： 或其生理上可接受的盐。
• Chemokine receptor anagonists and methods of use therefor
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20020169155A1

  公开（公告）日：2002-11-14

  Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: 1 or physiologically acceptable salt thereof.

  揭示了新颖的化合物以及一种治疗与异常白细胞召集和/或激活相关疾病的方法。该方法包括向需要的受试者施用化合物1或其生理上可接受的盐的有效量。
• CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR
  申请人：——

  公开号：US20020119973A1

  公开（公告）日：2002-08-29

  Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: 1 and physiologically acceptable salts thereof. 2

  披露了新颖的化合物以及一种治疗与异常白细胞招募和/或激活相关疾病的方法。该方法包括向需要治疗的主体施用一种有效量的化合物，该化合物由以下结构表示： 1 以及它们的生理可接受的盐。 2
• Chemokine receptor antagonists and methods of use thereof
  申请人：Luly R. Jay

  公开号：US20050070549A1

  公开（公告）日：2005-03-31

  Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.

  揭示了新化合物和一种治疗与异常白细胞召集和/或激活相关疾病的方法。该方法包括向需要的受试者施用由以下公式（1）表示的化合物或其生理上可接受的盐的有效量。
• [EN] TREATMENT OF METABOLIC SYNDROME WITH PIPERIDINE AMIDES<br/>[FR] TRAITEMENT DU SYNDROME MÉTABOLIQUE AVEC DES PIPÉRIDINAMIDES
  申请人：AMPLA PHARMACEUTICALS INC

  公开号：WO2011103126A1

  公开（公告）日：2011-08-25

  The present invention relates to piperidine derivatives of formula (I) and (II), their pharmaceutical compositions and methods of treatment of metabolic syndrome disorders such as obesity, diabetes, hypertension and hyperlipidemia using the said compounds. Formula (I) Formula (II) In formula (I), X and Y represent optionally substituted aryl or heteroaryl; R1 represents H or optionally substituted lower alkyl; R2 represents H, optionally substituted lower alkyl, ester, optionally substituted alkoxycarbonyl, acyl, thioester, thioacyl, thioether, optionally substituted alkoxyl, amino, optionally substituted aminoalkyl, amido or acylamino; and R3 represents H or OH. In formula (II), X represents optionally substituted aryl or heteroaryl; R4 represents H or optionally substituted lower alkyl; and R5 represents optionally substituted lower alkyl.

  本发明涉及式(I)和(II)的哌啶衍生物，其制药组合物和使用所述化合物治疗代谢综合征疾病，如肥胖症、糖尿病、高血压和高脂血症的方法。公式(I) 公式(II) 在公式(I)中，X和Y表示可选取代的芳基或杂环芳基；R1表示H或可选取代的较低烷基；R2表示H、可选取代的较低烷基、酯、可选取代的烷氧羰基、酰基、硫酯、硫酰基、硫醚、可选取代的烷氧基、氨基、可选取代的氨基烷基、酰胺或酰胺基；R3表示H或OH。在公式(II)中，X表示可选取代的芳基或杂环芳基；R4表示H或可选取代的较低烷基；R5表示可选取代的较低烷基。