2,4-Dichlor-triazinylisothiocyanat | 4267-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2,4-Dichlor-triazinylisothiocyanat
• 英文别名: 2,4-dichloro-6-isothiocyanato-[1,3,5]triazine；4,6-dichloro-[1,3,5]triazin-2-yl isothiocyanate；dichloro-[1,3,5]triazin-2-yl isothiocyanate；Dichlor-[1,3,5]triazin-2-ylisothiocyanat；2,4-Dichloro-6-isothiocyanato-1,3,5-triazine
• CAS: 4267-15-6
• 化学式: C₄Cl₂N₄S
• 分子量: 207.043
• InChiKey: RRVFGGBGCIJBHW-UHFFFAOYSA-N

物化性质

• 熔点：
  130-135 °C
• 沸点：
  132-134 °C(Press: 20 Torr)
• 密度：
  1.80±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2933699090

反应信息

• 作为反应物：
  描述：

  2,4-Dichlor-triazinylisothiocyanat 、 苯酚 、 二乙酸二丁基锡 生成 O-phenyl N-(4,6-dichloro-1,3,5-triazin-2-yl)carbamothioate
  参考文献：
  名称：

  KODAMA, XIROSI;KODAMA, TSUTOMU;SEHNOURA, MASAAKI;TANAKA, KATSUNORI

  摘要：

  DOI：
• 作为产物：
  描述：

  三聚氯氰 、 potassium thioacyanate 生成 2,4-Dichlor-triazinylisothiocyanat
  参考文献：
  名称：

  Isothiocyano-s-triazines

  摘要：

  公开号：

  US02864820A1

文献信息

• Methods for measuring the insulin receptor alpha subunit
  申请人：Ebina Yousuke

  公开号：US20070059784A1

  公开（公告）日：2007-03-15

  Presence of free insulin receptor α-subunit in blood was discovered. Furthermore, methods for measuring the insulin receptor α-subunit was provided, the method comprising the steps of contacting the insulin receptor α-subunit in a blood sample with an antibody recognizing the insulin receptor α-subunit, and detecting the binding between the two. Measurement of the free insulin receptor α-subunit in the blood is useful for evaluating risk factors for diabetes. In addition, the measurement methods of the present invention showed that concentrations of the free insulin receptor α-subunit in the blood of diabetes or cancer patients are significantly high. Free insulin receptor α-subunit in blood is useful as a marker for diabetes or cancer.

  发现了血液中存在游离胰岛素受体α亚单位。此外，提供了测量胰岛素受体α亚单位的方法，该方法包括将血液样品中的胰岛素受体α亚单位与识别胰岛素受体α亚单位的抗体接触，并检测两者之间的结合。测量血液中的游离胰岛素受体α亚单位有助于评估糖尿病的风险因素。此外，本发明的测量方法表明，糖尿病或癌症患者血液中游离胰岛素受体α亚单位的浓度显著高。血液中的游离胰岛素受体α亚单位可作为糖尿病或癌症的标志物。
• PEPTIDES CONTAINING RESPECTIVE AMINO ACID SEQUENCES SELECTED FROM AMONG THOSE OF LIPOPROTEIN(a) AND APOLIPOPROTEIN(a), ANTIBODIES RESPECTIVELY RECOGNIZING THESE AMINO ACID SEQUENCES, AND METHOD OF ASSAYING WITH THESE ANTIBODIES
  申请人：SHINO-TEST CORPORATION

  公开号：EP0621284A1

  公开（公告）日：1994-10-26

  Amino acid sequences which have a specificity as a lipoprotein(a) and are lowly homologous with LDL and plasminogen are selected from among the amino acid sequences of the lipoprotein(a) to obtain antibodies against the lipoprotein(a) which specifically recognize these amino acid sequences. At least one of these antibodies is used in the immunoassay of the lipoprotein(a). Amino acid sequences which have a specificity as an apolipoprotein(a) and do not have antigenicities as the lipoprotein(a) and plasminogen are selected from among the amino acid sequences of the apolipoprotein(a) to obtain antibodies against the apolipoprotein(a) which specifically recognize these amino acid sequences. At least one of these antibodies is used in the immunoassay of the apolipoprotein(a). The invention serves to prepare antibodies against lipoprotein(a) and apolipoprotein(a) more readily than the conventional methods and to conduct the immunoassay of the lipoprotein(a) and apolipoprotein(a) accurately by using the antibodies.

  从脂蛋白（a）的氨基酸序列中选择具有脂蛋白（a）特异性且与低密度脂蛋白和纤溶酶原同源性低的氨基酸序列，以获得特异性识别这些氨基酸序列的脂蛋白（a）抗体。这些抗体中至少有一种可用于脂蛋白（a）的免疫测定。从脂蛋白（a）的氨基酸序列中选择具有脂蛋白（a）特异性且不具有脂蛋白（a）和纤溶酶原抗原性的氨基酸序列，以获得特异性识别这些氨基酸序列的脂蛋白（a）抗体。这些抗体中至少有一种可用于脂蛋白（a）的免疫测定。与传统方法相比，本发明更容易制备针对脂蛋白（a）和载脂蛋白（a）的抗体，并利用这些抗体准确地进行脂蛋白（a）和载脂蛋白（a）的免疫测定。
• UROTHELIAL CANCER TUMOR MARKER
  申请人：TSS Biotech Inc.

  公开号：EP1605266A1

  公开（公告）日：2005-12-14

  This invention relates to a method for detecting urothelial carcinoma using an antibody that specifically reacts with a calreticulin protein or a fragment thereof and immunoassaying a calreticulin protein in a sample.

  本发明涉及一种使用与钙网蛋白或其片段特异性反应的抗体检测尿路癌的方法，以及对样本中钙网蛋白进行免疫测定的方法。
• COMPOSITION AND METHOD FOR DIAGNOSING ESOPHAGEAL CANCER AND METASTASIS OF ESOPHAGEAL CANCER
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1897940A1

  公开（公告）日：2008-03-12

  This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.

  本发明涉及一种由多核苷酸和抗体作为探针组成的组合物、试剂盒或 DNA 芯片，用于检测、确定或预测食管癌的存在或转移，还涉及使用该组合物、试剂盒或 DNA 芯片检测、确定或预测食管癌的存在或转移的方法。
• COMPOSITION AND METHOD FOR DIAGNOSING KIDNEY CANCER AND ESTIMATING KIDNEY CANCER PATIENT S PROGNOSIS
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1930426A1

  公开（公告）日：2008-06-11

  This invention relates to a composition, kit, DNA chip, and use thereof for detecting, diagnosing, and predicting metastasis of kidney cancer and/or for predicting the prognosis for kidney cancer, comprising one or a plurality of polynucleotides selected from the group consisting of polynucleotides, mutants thereof or fragments thereof, the expression levels of which vary in kidney cancer cells from a patient with a poor prognosis when compared with that in kidney cancer cells from a patient with a good prognosis; or antibodies or fragments thereof that bind specifically to polypeptides, mutants thereof or fragments thereof, the expression levels of which vary in the similar manner.

  本发明涉及一种用于检测、诊断和预测肾癌转移和/或预测肾癌预后的组合物、试剂盒、DNA 芯片及其用途，该组合物、试剂盒、DNA 芯片由一种或多种多核苷酸组成，这些多核苷酸选自由多核苷酸、其突变体或其片段组成的组，其在预后不良患者的肾癌细胞中的表达水平与在预后良好患者的肾癌细胞中的表达水平相比有所不同；或与多肽、其突变体或其片段特异性结合的抗体或其片段，其表达水平以类似方式变化。