phosphoric acid tris-(1-cyano-ethyl ester) | 85347-18-8

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 英文名称: phosphoric acid tris-(1-cyano-ethyl ester)
• 英文别名: Phosphorigsaeure-tris-(1-cyan-aethylester)；Tris-(1-cyan-aethoxy)-phosphin；tri-(1-cyanoethyl)phosphite；Tris(1-cyanoethyl) phosphite
• CAS: 85347-18-8
• 化学式: C₉H₁₂N₃O₃P
• 分子量: 241.186
• InChiKey: AFGBMAMNFVKBKF-UHFFFAOYSA-N

物化性质

• 沸点：
  152-154 °C(Press: 2 Torr)
• 密度：
  1.1188 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  99.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  phosphoric acid tris-(1-cyano-ethyl ester) 在 氧气 作用下， 生成 phosphoric acid tris-(1-cyano-ethyl ester)
  参考文献：
  名称：

  Kusnezow; Waletdinow, Metodičeskij sbornik, 1957, # 23, p. 161,165

  摘要：

  DOI：
• 作为产物：
  描述：

  乳腈 在 吡啶 、 乙醚 、 三氯化磷 作用下， 生成 phosphoric acid tris-(1-cyano-ethyl ester)
  参考文献：
  名称：

  Kusnezow; Waletdinow, Metodiceskij sbornik, 1957, # 23, p. 161,164

  摘要：

  DOI：

文献信息

• Process for preparing monoesters and diesters of N-alkyl substituted
  申请人：Monsanto Company

  公开号：US04442044A1

  公开（公告）日：1984-04-10

  A process for preparing monoesters and diesters of N-alkyl substituted amino methyl phosphonic acid which are useful as herbicides.

  一种制备N-烷基取代氨甲基膦酸单酯和二酯的过程，这些化合物可用作除草剂。
• Compounds and methods for the characterization of oligonucleotides
  申请人：Capaldi C. Daniel

  公开号：US20060040308A1

  公开（公告）日：2006-02-23

  The present invention relates to oligonucleotide synthesis. In particular, the present invention provides methods for characterizing samples useful for making oligonucleotides.

  本发明涉及寡核苷酸合成。具体而言，本发明提供了用于表征制备寡核苷酸所需样品的方法。
• Cyanoalkylphosphonate diesters of N-phosphonomethylglycinonitrile as
  申请人：Monsanto Company

  公开号：US04385921A1

  公开（公告）日：1983-05-31

  Alkylphosphonate diesters of N-phosphonomethylglycinonitrile are disclosed which are useful as herbicides. This invention further relates to herbicidal compositions containing such alkylphosphonate diesters of N-phosphonomethylglycinonitrile and to herbicidal methods employing such compounds and compositions.

  本发明揭示了N-磷酸甲基甘氨酸腈的烷基膦酸二酯，其可用作除草剂。本发明还涉及包含此类烷基膦酸二酯的除草剂组合物以及使用此类化合物和组合物的除草方法。
• Herbicidally active monoesters and diesters of n-alkyl substituted amino methyl phosphonic acid and process for preparing same
  申请人：MONSANTO COMPANY

  公开号：EP0068732A1

  公开（公告）日：1983-01-05

  Monoesters and diesters of N-alkyl-substituted amino methyl phosphonic acid of the formula wherein a + b = 2 and a is 0 or 1, Z, R and R, have various values, representative compounds being the ethyl, 2-chloroethyl, 2-ethoxyethyl and pentyl esters of N[(1-cyanoethoxy)hydroxy- phosphinyl]methylglycine, are made by reacting a phosphite of the formula P(OR1)3, water and a trisubstituted hexahydro-1,3,5-triazine of the formula Compounds of formula are useful as herbicides.

  式中 N-烷基取代氨基甲基膦酸的单酯和二酯 其中 a + b = 2，a 为 0 或 1，Z、R 和 R 具有不同的值，代表化合物为 N[(1-氰乙氧基)羟基-膦酰基]甲基甘氨酸的乙基酯、2-氯乙基酯、2-乙氧基乙基酯和戊基酯，由式 P(OR1)3、水和式三取代六氢-1,3,5-三嗪反应制得。 式化合物可用作除草剂。
• Mutation analysis by mass spectrometry using photolytically cleavable primers
  申请人：BRUKER-SAXONIA ANALYTIK GMBH

  公开号：EP1234888A2

  公开（公告）日：2002-08-28

  Summary The invention relates to a method of a mass-spectrometric analysis of known mutation sites in the genome, such as single nucleotide polymorphisms (SNPs), using the method of restricted primer extension. The invention consists of the use of primers with a photocleavable linker. The linker creates a gap in a DNA strand which is almost the same size as a natural DNA building block (nucleoside). The linker forms a bridge over a base pair without inhibiting hybridization or enzymatic extension. However, the linker allows the primers to be cleaved after extension in order to obtain short DNA fragments which can be more easily detected on the mass spectrometer.

  摘要 本发明涉及一种利用限制性引物延伸法对基因组中已知突变位点（如单核苷酸多态性（SNP））进行质谱分析的方法。 本发明包括使用带有光可裂解连接体的引物。连接体在 DNA 链上形成一个缺口，其大小与天然 DNA 构建块（核苷）几乎相同。连接体在碱基对上形成桥接，不会抑制杂交或酶延伸。不过，连接子允许引物在延伸后被裂解，以获得更容易在质谱仪上检测到的短 DNA 片段。