4-(1,3-Benzoxazol-2-yl)-1-(4-chloro-2-methylphenyl)-2,3,5,6-piperidinetetrone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(1,3-Benzoxazol-2-yl)-1-(4-chloro-2-methylphenyl)-2,3,5,6-piperidinetetrone
• 英文别名: 4-(1,3-benzoxazol-2-yl)-1-(4-chloro-2-methylphenyl)piperidine-2,3,5,6-tetrone
• 化学式: C₁₉H₁₁ClN₂O₅
• 分子量: 382.8
• InChiKey: BJZVDVOAEGMENU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  97.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• EGR1 TARGETING MOLECULES FOR THE TREATMENT OF INFLAMMATORY AND HYPERPROLIFERATIVE CONDITIONS
  申请人：The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center

  公开号：US20180289728A1

  公开（公告）日：2018-10-11

  A method of treating an inflammation or a hyperproliferative disease in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of: a compound represented by Formula I: or a pharmaceutically acceptable salt thereof, a compound represented by Formula II: and a compound represented by Formula III: wherein the variables in Formulae I, II and III are as defined in the specification.