4-tert-butyl-2-[2-[(4S)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]propan-2-yl]-4,5-dihydro-1,3-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 4-tert-butyl-2-[2-[(4S)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]propan-2-yl]-4,5-dihydro-1,3-oxazole
• 化学式: C₁₇H₃₀N₂O₂
• 分子量: 294.4
• InChiKey: DPMGLJUMNRDNMX-JHJMLUEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] AMINOPHENYLCYCLOPROPYL CARBOXYLIC ACIDS AND DERIVATIVES AS AGONISTS TO GPR40<br/>[FR] ACIDES AMINOPHENYLCYCLOPROPYLCARBOXYLIQUES ET LEURS DERIVES SERVANT D'AGONISTES DE GPR40
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005051890A1

  公开（公告）日：2005-06-09

  The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.

  本发明一般涉及新型治疗化合物，更具体地涉及新型化合物，它们作为GPR40激动剂的用途，它们的制造工艺以及在它们的制备中有用的中间体。
• 4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitor and a method of preparing same
  申请人：Dube Daniel

  公开号：US20070099951A1

  公开（公告）日：2007-05-03

  The invention is directed to a compound of the structural formula (22) crystal form of structural formulae (21) and its free acid, pharmaceutical compositions comprising these compounds and methods of preparing and using these compounds.

  该发明涉及结构式（22）晶体形式的化合物，结构式（21）及其游离酸，包括这些化合物的药物组合物以及制备和使用这些化合物的方法。
• AMINOPHENYLCYCLOPROPYL CARBOXYLIC ACIDS AND DERIVATIVES AS AGONISTS TO GPR40
  申请人：Corbett David Francis

  公开号：US20090105257A1

  公开（公告）日：2009-04-23

  The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.

  本发明通常涉及新型治疗化合物，更特别地涉及新型化合物，其用作GPR40激动剂，其制造过程以及其制备中有用的中间体。
• DEPROTECTION METHOD AND RESIN REMOVAL METHOD IN SOLID-PHASE REACTION FOR PEPTIDE COMPOUND OR AMIDE COMPOUND, AND METHOD FOR PRODUCING PEPTIDE COMPOUND
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP3889164A1

  公开（公告）日：2021-10-06

  The present inventors found that peptide compounds/amide compounds in which the protecting groups of interest are removed and/or which are removed from resins for solid-phase synthesis can be produced without main chain damage by contacting starting peptide compounds/amide compounds with silylating agents.

  本发明者发现，通过将起始肽化合物/酰胺化合物与硅烷化剂接触，可以生产出去除相关保护基团和/或从固相合成树脂中去除保护基团和/或从固相合成树脂中去除保护基团和/或从固相合成树脂中去除保护基团和/或从固相合成树脂中去除保护基团的肽化合物/酰胺化合物，而不会对主链造成破坏。
• US7834013B2
  申请人：——

  公开号：US7834013B2

  公开（公告）日：2010-11-16