4-(((Aminocarbonyl)oxy)imino)-1-benzylpiperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(((Aminocarbonyl)oxy)imino)-1-benzylpiperidine
• 英文别名: [(1-benzylpiperidin-4-ylidene)amino] carbamate
• 化学式: C₁₃H₁₇N₃O₂
• 分子量: 247.29
• InChiKey: OTTJCLRRNYGLSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] MDRI-INVERSE AGENTS<br/>[FR] AGENTS S'OPPOSANT AU GÈNE MDR1
  申请人：US HEALTH

  公开号：WO2010138686A1

  公开（公告）日：2010-12-02

  A method for inhibiting the growth of drug resistant cells in a subject, comprising identifying a subject having drug resistant cells; and administering to the subject a compound or a pharmaceutically acceptable salt or ester thereof, that is a MDR1 -inverse agent. Also disclosed is a method of inhibiting cancer in a subject, comprising administering to the subject an antiproliferative agent, wherein the antiproliferative effect of the agent is potentiated by P-glycoprotein and the agent is a compound, or a pharmaceutically acceptable salt or ester thereof, that is a MDR1 -inverse agent.