[5-(Carbamimidoylsulfanylmethyl)thiophen-2-yl]methyl carbamimidothioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: [5-(Carbamimidoylsulfanylmethyl)thiophen-2-yl]methyl carbamimidothioate
• 化学式: C₈H₁₂N₄S₃
• 分子量: 260.4
• InChiKey: XGDUNTSTRCLVLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  179
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES<br/>[FR] HYDRAZONES D'AMINOGUANIDINE EN TANT QUE STABILISATEURS RÉTROMÈRES UTILES POUR LE TRAITEMENT DE MALADIES NEUROLOGIQUES
  申请人：OSPEDALE SAN RAFFAELE SRL

  公开号：WO2020201326A1

  公开（公告）日：2020-10-08

  The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.

  本发明涉及一种新型氨基胍肼酮衍生物，其化学式为（I），可作为逆转体稳定剂，用作神经保护药物。本发明还涉及包含这些化合物的药物组合物，以及它们在治疗和诊断中的用途。
• AROMATIC AND HETEROAROMATIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS
  申请人：Cadieux Jean-Jacques

  公开号：US20100240713A1

  公开（公告）日：2010-09-23

  This invention is directed to compounds of formula (I), wherein m, formula (II), R 1 , R 2 and R 3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.

  本发明涉及式（I）的化合物，其中m、式（II）、R1、R2和R3如本文所定义，作为立体异构体、对映异构体、互变异构体或其混合物；或其药学上可接受的盐、溶剂或前药，用于治疗铁代谢紊乱。本发明还涉及包含该化合物的制药组合物以及使用该化合物治疗铁代谢紊乱的方法。
• TREATMENT OF AMYLOIDOSIS BY COMPOUNDS THAT REGULATE RETROMER STABILIZATION
  申请人：Brandeis University

  公开号：EP2787990A1

  公开（公告）日：2014-10-15
• RAB7L1 INTERACTS WITH LRRK2 TO MODIFY INTRANEURONAL PROTEIN SORTING AND PARKINSON'S DISEASE RISK
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF

  公开号：US20160250182A1

  公开（公告）日：2016-09-01

  The present invention relates to methods and compositions for treating Parkinson's Disease in a subject.
• AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES
  申请人：OSPEDALE SAN RAFFAELE SRL

  公开号：US20220213030A1

  公开（公告）日：2022-07-07

  The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.