(±)-pavine | 26919-05-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 栗碱生物碱
• 英文名称: (±)-pavine
• 英文别名: (+/-)-Pavin；2,3,8,9-tetramethoxy-5,6,11,12-tetrahydro-5,11-epimino-dibenzo[a,e]cyclooctene；2,3,8,9-Tetramethoxy-5,6,11,12-tetrahydro-5,11-epimino-dibenzo[a,e]cycloocten；Pavine；4,5,12,13-tetramethoxy-17-azatetracyclo[7.7.1.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaene
• CAS: 26919-05-1
• 化学式: C₂₀H₂₃NO₄
• 分子量: 341.407
• InChiKey: SRSPZLZVGPJHJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(4,5,12,13-Tetramethoxy-17-azatetracyclo[7.7.1.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaen-17-yl)ethanone 在 sodium hydroxide 作用下， 以 乙二醇甲醚 为溶剂， 生成 (±)-pavine
  参考文献：
  名称：

  Synthesis of new TNF-α Inhibitors and their biological properties

  摘要：

  New pavine alkaloid derivatives with various substitutions on their aromatic rings and nitrogen atom were prepared and evaluated for their inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS. Some compounds showed potent inhibitory activities in vitro and protected mice against lethality of septic shock induced by LPS and D-galactosamine. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00103-5

文献信息

• Synthesis of new TNF-α Inhibitors and their biological properties
  作者：Norio Fujiwara、Yutaka Ueda、Naohito Ohashi

  DOI：10.1016/0960-894x(96)00103-5

  日期：1996.4

  New pavine alkaloid derivatives with various substitutions on their aromatic rings and nitrogen atom were prepared and evaluated for their inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS. Some compounds showed potent inhibitory activities in vitro and protected mice against lethality of septic shock induced by LPS and D-galactosamine. Copyright (C) 1996 Elsevier Science Ltd

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