piperidine-1-carbothioic S-acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: piperidine-1-carbothioic S-acid
• 化学式: C₆H₁₁NOS
• 分子量: 145.23
• InChiKey: HFGGXBQZQRVOKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 2-GUANIDINO-4-OXO-IMIDAZOLINE DERIVATIVES AS ANTIMALARIAL AGENTS, SYNTHESIS AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS DE 2-GUANIDINO-4-OXO-IMIDAZOLINE EN TANT QU'AGENTS ANTIPALUDIQUES, SYNTHÈSE ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：US OF AMERICA AS REPRESENTED BY THE SECRETARY OF ARMY

  公开号：WO2012149093A1

  公开（公告）日：2012-11-01

  The present invention relates to new 2-guanidino-4-oxo-imidazoline derivatives (deoxo-IZ), methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

  本发明涉及新的2-胍基-4-氧代-咪唑啉衍生物（deoxo-IZ），制备这些化合物的方法，含有这些化合物的组合物，以及利用这些化合物预防、治疗或抑制受试者体内疟疾的方法。
• [EN] PEPTIDIC COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS<br/>[FR] COMPOSES PEPTIDIQUES EN TANT QU'INHIBITEURS DE LA PROTEASE A CYSTEINE
  申请人：AXYS PHARM INC

  公开号：WO2004000838A1

  公开（公告）日：2003-12-31

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及一种抑制半胱氨酸蛋白酶的化合物，特别是卡特普辛B、K、L、F和S，因此在治疗由这些蛋白酶介导的疾病方面具有用途。本发明涉及包含这些化合物的药物组合物以及制备它们的方法。
• SUBSTITUTED DIPIPERIDINE CCR2 ANTAGONISTS
  申请人：DeMong E. Duane

  公开号：US20070197590A1

  公开（公告）日：2007-08-23

  Substituted dipiperidine compounds of Formula (I) or a form thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.

  Formula (I)中的取代二哌啶化合物或其形式，它们是CCR2拮抗剂，可用于预防、治疗或改善需要的主体中的CCR2介导的炎症综合征、紊乱或疾病。
• [EN] ANTI-PARASITIC COMPOUNDS AND METHODS OF THEIR USE<br/>[FR] COMPOSES ANTIPARASITAIRES ET LEURS PROCEDES D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2005087211A1

  公开（公告）日：2005-09-22

  The present invention provides a novel class of compounds that disrupt the parasitic infectious life cycle and serve as promising agents for anti-parasitic therapy.

  本发明提供了一类新型化合物，可以破坏寄生虫的传染生命周期，并作为抗寄生虫疗法的有希望的药物。
• Substituted dipiperidine CCR2 antagonists
  申请人：Xia Mingde

  公开号：US20060069123A1

  公开（公告）日：2006-03-30

  Substituted dipiperidine compounds of Formula (I) or a salt, isomer, prodrug, metabolite or polymorph thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.

  Formula (I)的替代二哌啶化合物或其盐、异构体、前药、代谢物或多型体，其为CCR2拮抗剂，可用于预防、治疗或改善需要的主体中的CCR2介导的炎症综合症、紊乱或疾病。