2-Amino-4-methyl-piperidin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Amino-4-methyl-piperidin
• 英文别名: Aminopicoline；4-Methylpiperidin-2-amine
• 化学式: C₆H₁₄N₂
• 分子量: 114.191
• InChiKey: UHDGDGPBCVFSDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• HALOGEN-FREE RESIN COMPOSITION, AND PREPREG AND LAMINATE FOR PRINTED CIRCUITS USING THE SAME
  申请人：SHENGYI TECHNOLOGY CO., LTD.

  公开号：US20160024304A1

  公开（公告）日：2016-01-28

  Halogen-free resin composition, prepreg, and laminate for printed circuits using same. Based on 100 parts by weight of organic solid matter, the resin composition comprises: (A) bisphenol-type epoxy resin: 30˜60 parts by weight; (B) benzoxazine resin: 5˜45 parts by weight; (C) alkyl phenol novolac hardener: 10˜30 parts by weight; (D) phosphorus-containing flame retardant. The bisphenol-type epoxy resin, with numerous alkyl branched chains and benzene rings in its structure, makes the composition possess high glass transition temperature, low water absorption, good thermal resistance, and excellent dielectric properties. Taking the alkyl phenol novolac as the hardener can sufficiently exert the advantages of excellent dielectric properties and low water absorption resulted from containing numerous alkyls. The prepreg and laminate for printed circuits made from halogen-free resin composition have high glass transition temperature, low dielectric constant, low dielectric dissipation factor, low water absorption, high thermal resistance, and good flame retardancy, processability and chemical resistance.

  无卤素树脂组合物、预浸料以及使用该组合物的印制电路层压板。树脂组合物基于100份有机固体物质，包括：（A）双酚A型环氧树脂：30-60份重量；（B）苯并噁嗪树脂：5-45份重量；（C）烷基酚醛硬化剂：10-30份重量；（D）含磷阻燃剂。双酚A型环氧树脂具有许多烷基支链和苯环结构，使组合物具有高玻璃化转变温度、低吸水性、良好的耐热性和优异的介电性能。采用烷基酚醛硬化剂可以充分发挥含有许多烷基的优异介电性能和低吸水性的优点。使用无卤素树脂组合物制成的预浸料和印制电路层压板具有高玻璃化转变温度、低介电常数、低介电损耗因子、低吸水性、高耐热性、良好的阻燃性、加工性和化学耐性。
• NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF
  申请人：Eisai Co., Ltd.

  公开号：EP1382603A1

  公开（公告）日：2004-01-21

  The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. Inparticular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, X represents a nitrogen-containing condensed aromatic heterocyclic group such as imidazo[1,2-a]pyridine, benzimidazole, quinazoline, quinoline, or 2,1-benzisoxazole and has (R4)n as substituent groups; Y represents a C3-8 cycloalkyl group, C4-8 cycloalkenyl group, 5- to 14-membered non-aromatic heterocyclic group, C6-14 aromatic hydrocarbon cyclic group or 5- to 14-membered aromatic heterocyclic group; n in (R4)n is 0, 1, 2 or 3, and Z groups independently represent (1) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, (16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) (i) C3-7cycloalkyl group, (ii) C3-7cycloalkenyl group, (iii) 5- to 14-membered non-aromatic heterocyclic group, each of which may have one or more substituent groups Q, or (19) formula -M1-M2-M3, R1 represents (1) hydrogen atom, (2) halogen atom, (3) hydroxyl group, (4) nitro group, (5) cyano group, (6) halogenated C1-6 alkyl group, (7) C2-6 alkyl group substituted with a hydroxyl or cyano group, (8) C2-6 alkenyl group, or (9) formula -L1-L2-L3, and R2 represents a hydrogen atom or a protecting group; and R3 represents a hydrogen atom, halogen atom, cyano group, amino group, C1-4 alkyl group or halogenated C1-4 alkyl group.

  本发明提供了一种对 STAT6 的活化具有极佳抑制作用的化合物及其药物组合物。特别是提供了由下式（I）代表的化合物、其盐或它们的水合物。 式中，X代表含氮缩合芳香杂环基团，如咪唑并[1,2-a]吡啶、苯并咪唑、喹唑啉、喹啉或2,1-苯并异噁唑，并有(R4)n作为取代基；Y代表C3-8环烷基、C4-8环烯基、5～14元非芳香杂环基团、C6-14芳香烃环基或5～14元芳香杂环基团；(R4)n 中的 n 是 0、1、2 或 3，Z 基团独立地代表：(1) 氢原子，(2) 氨基，(3) 卤素原子，(4) 羟基，(5) 硝基，(6) 氰基，(7) 叠氮基，(8) 甲酰基，(9) 羟基氨基、(10) 氨基磺酰基，(11) 氨基胍基，(12) 氧代基，(13) C2-6 烯基，(14) C1-6 烷氧基，(15) C1-6 烷基羟基氨基，(16) 卤代 C1-6 烷基，(17) 卤代 C2-6 烯基，(18) (i) C3-7 环烷基、(ii) C3-7 环烯基，(iii) 5-14 元非芳杂环基团，其中每个基团可有一个或多个取代基 Q，或 (19) 式-M1-M2-M3，R1 代表 (1) 氢原子，(2) 卤素原子，(3) 羟基、(4) 硝基，(5) 氰基，(6) 卤代 C1-6 烷基，(7) 被羟基或氰基取代的 C2-6 烷基，(8) C2-6 烯基，或 (9) 式-L1-L2-L3，R2 代表氢原子或保护基团；R3 代表氢原子、卤素原子、氰基、氨基、C1-4 烷基或卤代 C1-4 烷基。
• Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2048142A2

  公开（公告）日：2009-04-15

  The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. In particular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the groups X,Y,Z,R1-R4 and n are defined as in claim 1.

  本发明提供了一种对 STAT6 的活化具有极佳抑制作用的化合物及其药物组合物。特别是提供了由下式（I）代表的化合物、其盐或它们的水合物。 式中，基团 X、Y、Z、R1-R4 和 n 的定义如权利要求 1 所述。
• Epoxy resin composition, and prepreg and copper clad laminate made therefrom
  申请人：Shengyi Technology Co., Ltd.

  公开号：EP2706091A1

  公开（公告）日：2014-03-12

  The present invention relates to an epoxy resin composition, and a prepreg and a copper clad laminate made therefrom. The epoxy resin composition comprises: (A) epoxy resin containing two or over two epoxy groups, (B) active ester curing agent, and (C) phosphate salt compound. The epoxy resin composition of the present invention adopts epoxy resin with specific molecular structure, which has comparatively high functionality, so the cured products have high glass transition temperature and low hydroscopic property; active ester is adopted as the curing agent to make full use of the advantages that polar groups will not be produced when the active ester reacts with the epoxy resin; the prepreg and copper clad laminate made therefrom of the present invention can achieve halogen-free flame retardance, and meanwhile have excellent dielectric properties and good resistance to humidity and heat.

  本发明涉及一种环氧树脂组合物，以及由其制成的预浸料和覆铜板。环氧树脂组合物包括：(A) 含有两个或两个以上环氧基团的环氧树脂；(B) 活性酯固化剂；(C) 磷酸盐化合物。本发明的环氧树脂组合物采用具有特定分子结构的环氧树脂，其官能度相对较高，因此固化后的产品具有较高的玻璃化温度和较低的水相性质；采用活性酯作为固化剂，充分利用了活性酯与环氧树脂反应时不会产生极性基团的优点；本发明的预浸料及其制成的覆铜板可实现无卤阻燃，同时具有优异的介电性能和良好的耐湿耐热性能。
• Halogen-free resin composition, and prepreg and laminate for printed circuits using the same
  申请人：Shengyi Technology Co., Ltd

  公开号：EP2977405A1

  公开（公告）日：2016-01-27

  The present invention relates to a halogen-free resin composition, and prepreg and laminate for printed circuits using same. Based on 100 parts by weight of the organic solid matter, the resin composition comprises: (A) bisphenol-type epoxy resin : 30∼60 parts by weight; (B) benzoxazine resin: 5∼45 parts by weight; (C) alkyl phenol novolac hardener: 10∼30 parts by weight; (D) phosphorus-containing flame retardant. The bisphenol-type epoxy resin, with lots of alkyl branched chains and benzene rings in its structure, makes the composition possesse high glass transition temperature, low water absorption, good thermal resistance as well as excellent dielectric properties; Taking the alkyl phenol novolac as the hardener can sufficiently exert the advantages of excellent dielectric properties and low water absorption resulted from containing lots of alkyls. The prepreg and laminate for printed circuits made from the halogen-free resin composition have high glass transition temperature, low dielectric constant, low dielectric dissipation factor, low water absorption, high thermal resistance and good flame retardancy, processability and chemical resistance.

  本发明涉及一种无卤素树脂组合物，以及使用该组合物的印刷电路预浸料和层压板。以 100 重量份的有机固体物质为基准，该树脂组合物包括：(A) 双酚型环氧树脂：30∼60 重量份；(B) 苯并恶嗪树脂5∼45 份（重量比）； (C) 烷基酚酚醛固化剂：(D) 含磷阻燃剂。双酚型环氧树脂的结构中含有大量的烷基支链和苯环，使其具有玻璃化温度高、吸水率低、耐热性好、介电性能优异等特点；以烷基酚酚醛为固化剂，可以充分发挥含有大量烷基所带来的介电性能优异、吸水率低等优点。用无卤树脂组合物制成的印制电路预浸料和层压板具有高玻璃化温度、低介电常数、低介电损耗因子、低吸水性、高耐热性和良好的阻燃性、加工性和耐化学性。