1,2,3,5,6,7,8,8a-Octahydroindolizine-1,7,8-triol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚里西啶
• 英文名称: 1,2,3,5,6,7,8,8a-Octahydroindolizine-1,7,8-triol
• 化学式: C₈H₁₅NO₃
• 分子量: 173.21
• InChiKey: UOCBJSROECMAOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• EP0532530A4
  申请人：——

  公开号：EP0532530A4

  公开（公告）日：1993-05-26
• DERIVATIVES OF 6-AMINOOCTAHYDROINDOLIZINETRIOL
  申请人：MERRELL PHARMACEUTICALS INC.

  公开号：EP0532530B1

  公开（公告）日：1997-07-23
• Treatment of degenerative cartilage conditions in a mammal with Glycosidasc Inhibitors
  申请人：Ichikawa Yoshitaka

  公开号：US20070197471A1

  公开（公告）日：2007-08-23

  This invention relates to treating, preventing, and lessening the severity of conditions selected from the group consisting of osteoarthritis, rheumatoid arthritis, synovitis, subchondral bone edema, and cartilage degradation with administration of glycosidase inhibitors.
• Selective Glycosidase Inhibitors and Uses Thereof
  申请人：Simon Fraser University

  公开号：US20140051719A1

  公开（公告）日：2014-02-20

  The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
• US5079254A
  申请人：——

  公开号：US5079254A

  公开（公告）日：1992-01-07