2,3,5-Triphenyltetrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2,3,5-Triphenyltetrazole
• 英文别名: 2,3,5-triphenyl-1H-tetrazole
• 化学式: C₁₉H₁₆N₄
• 分子量: 300.4
• InChiKey: QOIRFXTZHVPXLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Cardioprotective tocopherol analogs
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0369083A1

  公开（公告）日：1990-05-23

  This invention relates to quatenary ammonium salts of certain 2H-1-benzopyran derivatives, to intermediates and proces­ses useful for their preparation, to their free-radical scavenger and cellular protective properties and to their end-use applica­tion as therapeutic agents.

  这项发明涉及某些2H-1-苯并吡喁衍生物的季铵盐，以及用于它们的制备的中间体和工艺，它们的自由基清除剂和细胞保护性能，以及它们作为治疗剂的最终应用。
• [EN] BENZOPYRAN DERIVATIVES SUBSTITUTED WITH SECONDARY AMINES INCLUDING IMIDAZOLE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES DE BENZOPYRANE SUBSTITUES PAR DES AMINES SECONDAIRES DONT IMIDAZOLE, PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2004014898A1

  公开（公告）日：2004-02-19

  The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present invention is pharmacologically useful for the treatment of cancer, rheumatoid arthritis, and diabetic retinopathies through anti-angiogenic properties, and also pharmacologically useful in the protection of heart and neuronal cells against ischemia-reperfusion injury or preserving organs.

  本发明涉及取代了次级胺（包括咪唑）的苯并吡喃衍生物，以及其制备方法和含有它们的药物组合物。本发明在药理学上可用于治疗癌症、类风湿性关节炎和糖尿病视网膜病变，通过抗血管生成的特性，同时在保护心脏和神经细胞免受缺血再灌注损伤或保存器官方面也具有药理学上的用途。
• [EN] SK AND IK CHANNEL AGONISTS FOR TREATMENT OF HEART FAILURE<br/>[FR] AGENTS AGONISTES DES CANAUX SK ET IK POUR LE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE
  申请人：UNIV COLUMBIA

  公开号：WO2016191294A1

  公开（公告）日：2016-12-01

  The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable carrier and a compound of the present invention are also provided. Methods and kits for treating or ameliorating the effects of heart failure syndrome, high blood pressure and diabetes also are provided. Methods, kits and compositions which include compounds of the present invention also are provided.

  本发明提供了改进的钾通道激动剂化合物。还提供了包括药用可接受载体和本发明化合物的制药组合物。还提供了用于治疗或缓解心力衰竭综合症、高血压和糖尿病的方法和工具包。还提供了包括本发明化合物的方法、工具包和组合物。
• [EN] BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES HETEROCYCLIQUES DE BENZOPYRANYLE, METHODE DE PREPARATION DESDITS DERIVES ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：DONGBU HANNONG CHEMICAL CO LTD

  公开号：WO2002030925A1

  公开（公告）日：2002-04-18

  The present invention relates to novel benzopyranyl heterocycle derivatives, process for preparation thereof and pharmaceutical use of the benzopyranyl heterocycle derivatives. The benzopyranyl heterocycle derivatives of the present invention can be used for protecting heart, brain, retina and neuronal cell from 'ischemia-reperfusion' injury, treatment for diseases related to it and suppressing lipid peroxidation.

  本发明涉及新型苯并吡喃杂环衍生物、其制备方法和苯并吡喃杂环衍生物的药用。本发明的苯并吡喃杂环衍生物可用于保护心脏、大脑、视网膜和神经细胞免受“缺血再灌注”损伤，治疗与之相关的疾病以及抑制脂质过氧化反应。
• [EN] BENZOPYRANYL GUANIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES DE BENZOPYRANYLE GUANIDINE, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2001029023A1

  公开（公告）日：2001-04-26

  The present invention relates to novel benzopyranyl guanidine derivatives of formula (1), wherein R1, R2, R3, R4, R5, R6, n and * are each defined in specification, process for preparation thereof and pharmaceutical use of the benzopyranyl guanidine derivatives. The benzopyranyl guanidine derivatives of the present invention can be used for protecting heart, neuronal cell or brain damage, preserving organs, and also the benzopyranyl guanidine derivatives are pharmacologically useful for inhibiting NO generation, and for suppressing lipid peroxidation, angiogenesis or restenosis.

  本发明涉及一种新型苯并吡啶基胍衍生物，其化学式为（1），其中R1，R2，R3，R4，R5，R6，n和*在规范中各自定义，制备过程以及苯并吡啶基胍衍生物的药用。本发明的苯并吡啶基胍衍生物可用于保护心脏、神经细胞或脑损伤，保护器官，也可用于药理学上抑制NO的生成，抑制脂质过氧化，抑制血管生成或再狭窄。