Sulfone, butyl isopropyl

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: Sulfone, butyl isopropyl
• 英文别名: 1-propan-2-ylsulfonylbutane
• 化学式: C₇H₁₆O₂S
• 分子量: 164.27
• InChiKey: GHWLXARFRZMOHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Water-Soluble CC-1065 Analogs and Their Conjugates
  申请人：Beusker Patrick Henry

  公开号：US20090318668A1

  公开（公告）日：2009-12-24

  This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

  这项发明涉及DNA结合烷基化剂CC-1065的新型类似物及其结合物。此外，该发明涉及用于制备上述剂和它们的结合物的中间体。这些结合物设计为在一个或多个激活步骤之后以及/或由结合物控制的速率和时间跨度下释放它们的（多种）荷载，以便选择性地传递和/或可控地释放一个或多个所述的DNA烷基化剂。这些剂、结合物和中间体可用于治疗以不良（细胞）增殖为特征的疾病。例如，这项发明的剂和结合物可用于治疗肿瘤。
• [EN] FUNGICIDAL COMPOSITIONS<br/>[FR] COMPOSITIONS FONGICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2012146125A1

  公开（公告）日：2012-11-01

  The present invention provides a composition comprising a combination of components A) and B), wherein component A) is a compound of formula (I) and the component (B) is a further fungicide, insecticide or herbicide.

  本发明提供了一种包含组分A)和B)的组合物，其中组分A)是化合物的公式(I)，组分B)是另一种杀真菌剂、杀虫剂或除草剂。
• FUNGICIDAL COMPOSITIONS
  申请人：Haas Ulrich Johannes

  公开号：US20140335201A1

  公开（公告）日：2014-11-13

  The present invention provides a composition comprising a combination of components A) and B), wherein component A) is a compound of formula (I) and the component (B) is a further fungicide, insecticide or herbicide.

  本发明提供了一种组合物，包括组分A)和B)，其中组分A)是化合物的公式(I)，组分B)是另一种杀真菌剂、杀虫剂或除草剂。
• SULFONE COMPOUND
  申请人：Sumitomo Seika Chemicals Co. Ltd.

  公开号：EP2351735A1

  公开（公告）日：2011-08-03

  It is an object of the present invention to provide an aprotic polar solvent mainly useful as a solvent for an electrochemical device, and having a comparatively low melting point and excellent thermal stability. The present invention is a sulfone compound represented by the following formula (1), wherein, in the formula (1), R1 and R2 each represent a C3-C6 alkyl group, and R1 and R2 are different.

  本发明的目的是提供一种无质子极性溶剂，主要用作电化学装置的溶剂，具有相对较低的熔点和优异的热稳定性。本发明是一种由以下式子（1）所表示的磺酰化合物，其中，在式（1）中，R1和R2各代表C3-C6烷基，且R1和R2不同。
• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。