1-allyl-1,3-dihydro-imidazole-2-thione | 121690-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 1-allyl-1,3-dihydro-imidazole-2-thione
• 英文别名: 1-Allyl-1,3-dihydro-imidazol-2-thion；1-Allylimidazole-2-thione；3-prop-2-enyl-1H-imidazole-2-thione
• CAS: 121690-22-0
• 化学式: C₆H₈N₂S
• mdl: MFCD19159731
• 分子量: 140.209
• InChiKey: CBOFNIXCXGDHQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  18.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 4-Aralkyl-5-substituted-1,2,4-triazole-5-thiols
  申请人：SMITHKLINE BECKMAN CORPORATION

  公开号：EP0323737A1

  公开（公告）日：1989-07-12

  Compounds of formula (I) and pharmaceutically acceptable salts thereof are described in which, n is 0 to 5; X¹ to X⁵ are any accessible combination of hydrogen, halogen, C₁₋₆alkyl, C₁₋₆alkoxy, cyano, nitro, SONH₂, SO₂NH₂, SO₂CH₃, SO₂CH₂F, SO₂CHF₂, SO₂CF₃, CF₃, CHO, OH, CH₂OH, CO₂H, or CO₂CpH2p+1 wherein p is 1 to 4; R¹ is phenyl substituted by X¹ to X⁵, C₁₋₄alkyl, C₃₋₆cycloalkyl, or an arylC₁₋₄alkyl group substituted by X¹ to X⁵; R² is hydrogen, C₁₋₄alkyl or (CH₂)m-CO₂R³; m is 0 to 5; and R³ is H or C₁₋₄alkyl. These compounds are dopamine-β-hydroxylase inhibitors. Pharmaceutical compositions are described as are methods of use. Processes for the preparation of these compounds are described.

  描述了式（I）的化合物及其药学上可接受的盐，其中，n为0至5；X¹至X⁵为氢、卤素、C₁₋₆烷基、C₁₋₆烷氧基、氰基、硝基、SONH₂、SO₂NH₂、SO₂CH₃、SO₂CH₂F、SO₂CHF₂、SO₂CF₃、CF₃、CHO、OH、CH₂OH、CO₂H或CO₂CpH2p+1的任意可访问组合，其中p为1至4；R¹为被X¹至X⁵取代的苯基、C₁₋₄烷基、C₃₋₆环烷基或被X¹至X⁵取代的芳基C₁₋₄烷基基团；R²为氢、C₁₋₄烷基或（CH₂）m-CO₂R³；m为0至5；R³为H或C₁₋₄烷基。这些化合物是多巴胺-β-羟基化酶抑制剂。描述了药物组合物以及使用方法。描述了这些化合物的制备过程。
• Dopamine-beta hydroxylase inhibitors
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0359505A1

  公开（公告）日：1990-03-21

  Dopamine-β-hydroxylase inhibitors of structure: in which R¹ is pyridyl or pyridylalkyl, pharmaceutical compositions containing them and their use in therapy in lowering blood pressure.

  多巴胺-β-羟化酶抑制剂的结构：其中R¹为吡啶基或吡啶基烷基，包含它们的药物组合物以及它们在降低血压治疗中的用途。
• Dopamine-beta-hydroxylase inhibitors
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0371732A1

  公开（公告）日：1990-06-06

  Dopamine-β-hydroxylase inhibitors of structure: pharmaceutical compositions containing them and their use in methods of lowering blood pressure in mammals.

  多巴胺-β-羟化酶抑制剂的结构：含有它们的药物组合物及其在降低哺乳动物血压方法中的应用。
• Dopamine-B-Hydroxylase inhibitors
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0371730A1

  公开（公告）日：1990-06-06

  Dopamine-β-hydroxylase inhibitors of structure: pharmaceutical compositions containing them and their use in methods of lowering blood pressure in mammals.

  多巴胺-β-羟化酶抑制剂的结构：包含它们的制药组合物以及它们在哺乳动物降低血压方法中的应用。
• Nematicidal trifluorobutenyl imidazole thioether derivatives
  申请人：Watanabe Yukiyoshi

  公开号：US20050080123A1

  公开（公告）日：2005-04-14

  The present invention relates to novel trifluorobutenyl imidazole thioether derivatives of the following formula (1) wherein R 1 represents hydrogen or halogen, R 2 represents hydrogen, halogen or alkoxycarbonyl, R 3 represents hydrogen, alkyl, alkenyl, cycloalkyl or aralkyl, and n represents 0,1 or 2, with the proviso that R 1 , R 2 and R 3 do not all represent hydrogen at the same time to a process for their preparation and to their use as nematicides.

  本发明涉及以下式(1)的新型三氟丁烯基咪唑硫醚衍生物，其中R1代表氢或卤素，R2代表氢、卤素或烷氧羰基，R3代表氢、烷基、烯基、环烷基或芳基烷基，n代表0、1或2，但R1、R2和R3不同时均代表氢，以及其制备方法和作为杀线虫剂的用途。