Thiophene, 2,5-bis(2-methylpropyl)-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: Thiophene, 2,5-bis(2-methylpropyl)-
• 英文别名: 2,5-bis(2-methylpropyl)thiophene
• 化学式: C₁₂H₂₀S
• 分子量: 196.35
• InChiKey: DUKLFSDDEVHMJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PYRIDONS AS PDK1 INHIBITORS
  申请人：Engelhardt Harald

  公开号：US20110269958A1

  公开（公告）日：2011-11-03

  The present invention encompasses compounds of general formula (1) while the groups R 4 to R 7 and the units W, L, Q a and Q H are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.

  本发明涵盖了一般式（1）的化合物，其中R4到R7和单位W、L、Qa和QH的定义如权利要求1所述，适用于治疗由过度或异常细胞增殖特征的疾病，并且它们作为具有上述特性的药物的用途。
• RESIN COMPOSITION, STRETCHED FILM, CIRCULARLY POLARIZING PLATE, AND IMAGE DISPLAY DEVICE
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20150247002A1

  公开（公告）日：2015-09-03

  The invention relates to a resin composition which comprises a polymer having a divalent oligofluorene as a repeating unit therein, wherein the divalent oligofluorene contains at least two fluorene units optionally having a substituent, and the 9-positioned carbon atoms of the fluorene units bond to each other via a direct bond or via an alkylene group optionally having a substituent, an arylene group optionally having a substituent, or an aralkylene group optionally having a substituent, and a ratio of a retardation measured at a wavelength of 450 nm (Re450) to a retardation measured at a wavelength of 550 nm (Re550) satisfies the following formula (2): Re450/Re550≦1.0.

  本发明涉及一种树脂组合物，其中包括具有二价寡聚芴作为重复单元的聚合物，其中二价寡聚芴包含至少两个芴单元，可选地具有取代基，并且芴单元的9位碳原子通过直接键或通过可选具有取代基的烷基、芳基或芳基烷基相互结合。在450nm波长（Re450）和550nm波长（Re550）下测得的减速比之比（Re450/Re550）符合以下公式（2）：Re450/Re550≦1.0。
• Benzimidazole derivatives
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US10017499B2

  公开（公告）日：2018-07-10

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）化合物或其药学上可接受的盐、酯或原药： 它们能抑制含 RNA 的病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物可干扰丙型肝炎病毒的生命周期，也可用作抗病毒药物。本发明进一步涉及包含上述化合物的药物组合物，用于给丙型肝炎病毒感染者用药。本发明还涉及通过施用包含本发明化合物的药物组合物治疗受试者感染 HCV 的方法。
• Aqueous dispersions including polyester particles, photopolymerizable compositions, articles, and methods
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US11091579B2

  公开（公告）日：2021-08-17

  The present disclosure provides an aqueous dispersion. The aqueous dispersion includes a) water; b) a surfactant having at least one ethylenically unsaturated group; and c) polyester particles dispersed in the water. The polyester particles include a water-insoluble polyester having a weight average molecular weight of 20 kiloDaltons or greater, and the polyester particles have an average diameter that is submicron in size. Further, the present disclosure provides a method of making the aqueous dispersion. The method includes a) dissolving a water-insoluble polyester in a water-immiscible solvent to form a polyester solution; b) combining the polyester solution with an aqueous solution including water and a surfactant; and c) removing at least a portion of the water-immiscible solvent to form the aqueous dispersion including polyester particles dispersed in the water. The present disclosure also provides a photopolymerizable composition including a) water; b) a surfactant; c) polyester particles dispersed in the water; d) a photoinitiator; e) at least one ethylenically unsaturated monomer dispersed in the water; and f) an optional polymerization inhibitor. The present disclosure also provides coatings and articles prepared from the aqueous dispersion or photopolymerizable composition.

  本公开提供了一种水性分散体。该水分散液包括 a) 水；b) 具有至少一个乙烯不饱和基团的表面活性剂；以及 c) 分散在水中的聚酯颗粒。聚酯颗粒包括重量平均分子量大于或等于 20 千道尔顿的水不溶性聚酯，聚酯颗粒的平均直径为亚微米级。此外，本公开还提供了一种制造水性分散体的方法。该方法包括 a) 将不溶于水的聚酯溶解在不溶于水的溶剂中，形成聚酯溶液；b) 将聚酯溶液与包括水和表面活性剂的水溶液混合；以及 c) 去除至少一部分不溶于水的溶剂，形成包括分散在水中的聚酯颗粒的水性分散体。本公开还提供了一种可光聚合组合物，包括 a) 水；b) 表面活性剂；c) 分散在水中的聚酯颗粒；d) 光引发剂；e) 至少一种分散在水中的乙烯基不饱和单体；以及 f) 任选的聚合抑制剂。本公开还提供了由水性分散体或可光聚合组合物制备的涂料和物品。
• Photopolymerizable compositions including a polyurethane methacrylate polymer prepared using a polycarbonate diol, articles, and methods
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US11225535B2

  公开（公告）日：2022-01-18

  The present disclosure provides a photopolymerizable composition. The photopolymerizable composition includes a) 40-60 parts by weight of a monofunctional (meth)acrylate monomer, per 100 parts of the total photopolymerizable composition; b) a photoinitiator; and c) a polymerization reaction product of components. A cured homopolymer of the monofunctional (meth)acrylate monomer has a glass transition temperature of 125 degrees Celsius or greater. The polymerization reaction product of components includes i) a diisocyanate; ii) a hydroxy functional methacrylate; iii) a polycarbonate diol; and iv) a catalyst. The polymerization reaction product includes a polyurethane methacrylate polymer. Often, the polycarbonate diol has a number average molecular weight of greater than 1,000 grams per mole (g/mol) or a weighted average of all polycarbonate diols present in the components has a Mn of greater than 1,000 g/mol; alternatively, the polyurethane methacrylate polymer has a weight average molecular weight of 8,000 g/mol or greater. An article is also provided including the photopolymerizable composition reaction product. Further, the present disclosure provides articles and methods of making articles. Methods are additionally provided, including receiving, by a manufacturing device having one or more processors, a digital object comprising data specifying an article; and generating, with the manufacturing device by an additive manufacturing process, the article based on the digital object. A system is also provided, including a display that displays a 3D model of an article; and one or more processors that, in response to the 3D model selected by a user, cause a 3D printer to create a physical object of an article.

  本公开提供了一种可光聚合组合物。这种可光聚合组合物包括 a) 按重量计，每 100 份可光聚合组合物中含 40-60 份单官能团（甲基）丙烯酸酯单体；b) 光引发剂；以及 c) 各组分的聚合反应产物。单官能团（甲基）丙烯酸酯单体的固化均聚物的玻璃化温度为 125 摄氏度或更高。组分的聚合反应产物包括 i) 二异氰酸酯；ii) 羟基官能甲基丙烯酸酯；iii) 聚碳酸酯二元醇；和 iv) 催化剂。聚合反应产物包括聚氨酯甲基丙烯酸酯聚合物。通常，聚碳酸酯二元醇的数均分子量大于 1,000 克/摩尔（g/mol），或存在于组分中的所有聚碳酸酯二元醇的加权平均分子量大于 1,000 克/摩尔；或者，聚氨酯甲基丙烯酸酯聚合物的重量平均分子量大于或等于 8,000 克/摩尔。还提供了一种包括可光聚合组合物反应产物的物品。此外，本公开还提供了物品和制作物品的方法。另外还提供了方法，包括由具有一个或多个处理器的制造设备接收数字对象，该数字对象包括指定物品的数据；以及由制造设备通过增材制造工艺基于数字对象生成物品。还提供了一种系统，包括显示物品三维模型的显示器；以及一个或多个处理器，这些处理器响应用户选择的三维模型，使三维打印机创建物品的物理对象。