Silane, (iodomethyl)dimethylpropyl-

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: Silane, (iodomethyl)dimethylpropyl-
• 英文别名: iodomethyl-dimethyl-propylsilane
• 化学式: C₆H₁₅ISi
• 分子量: 242.175
• InChiKey: NQRKKHGWHOEHMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.08
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  Silane, (iodomethyl)dimethylpropyl- 在 palladium on activated charcoal 甲醇 、 甲酸 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2R,3R,4R,5S)-1-(Dimethyl-propyl-silanylmethyl)-2-hydroxymethyl-piperidine-3,4,5-triol
  参考文献：
  名称：

  New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases

  摘要：

  New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (K-i, t(1/2)) for inhibition of rat intestinal alpha-glucohydrolases as well as human lysosomal alpha-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal alpha-glucohydrolases. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00012-7

文献信息

• Foeldeak, Sandor; Molnar, Maria; Lokoes, Magdalena, Liebigs Annalen der Chemie, 1994, # 2, p. 211 - 212
  作者：Foeldeak, Sandor、Molnar, Maria、Lokoes, Magdalena

  DOI：——

  日期：——
• New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases
  作者：Brigitte Lesur、Jean-Bernard Ducep、Marie-Noelle Lalloz、Anne Ehrhard、Charles Danzin

  DOI：10.1016/s0960-894x(97)00012-7

  日期：1997.2

  New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (K-i, t(1/2)) for inhibition of rat intestinal alpha-glucohydrolases as well as human lysosomal alpha-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal alpha-glucohydrolases. (C) 1997, Elsevier Science Ltd.