Piperidine, 4-(1,1-dimethylethyl)-1-phenyl-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Piperidine, 4-(1,1-dimethylethyl)-1-phenyl-
• 英文别名: 4-tert-butyl-1-phenylpiperidine
• 化学式: C₁₅H₂₃N
• 分子量: 217.35
• InChiKey: ANFQLEUKEUFKDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Pyrazole Amide Derivatives, Compositions Containing Such Compounds And Methods Of Use
  申请人：Beeson Teresa

  公开号：US20070203186A1

  公开（公告）日：2007-08-30

  Pyrazole amides are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

  本文介绍了吡唑酰胺类化合物，其适用于治疗2型糖尿病及相关疾病。同时还包括药物组合物和治疗方法。
• QUINOLINONE-PYRAZOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
  申请人：Beshore Douglas C.

  公开号：US20120196845A1

  公开（公告）日：2012-08-02

  The present invention is directed to quinolinone-pyrazolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

  本发明涉及公式（I）的喹啉酮-吡唑酮化合物，它们是M1受体正向变构调节剂，可用于治疗M1受体参与的疾病，如阿尔茨海默病、精神分裂症、疼痛或睡眠障碍。本发明还涉及包括上述化合物的制药组合物，以及在治疗M1受体介导的疾病中使用上述化合物和组合物的方法。
• HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6
  申请人：TES Pharma S.r.l.

  公开号：US20210323942A1

  公开（公告）日：2021-10-21

  The present disclosure relates to compounds capable of modulating the activity of NR2F6. The compounds of the disclosure may be used in methods for the prevention and/or the treatment of diseases and disorders associated with modulating NR2F6 activity.
• US7649009B2
  申请人：——

  公开号：US7649009B2

  公开（公告）日：2010-01-19
• US8895580B2
  申请人：——

  公开号：US8895580B2

  公开（公告）日：2014-11-25