1-Triisopropylsilyloxynonane

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1-Triisopropylsilyloxynonane
• 英文别名: nonoxy-tri(propan-2-yl)silane
• 化学式: C₁₈H₄₀OSi
• 分子量: 300.6
• InChiKey: QVDITAQUFPRLJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.93
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Triisopropylsilyloxynonane 在 palladium on activated charcoal 氢气 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以94%的产率得到1-壬醇
  参考文献：
  名称：

  Silyl group deprotection by Pd/C/H2. A facile and selective method

  摘要：

  An easy, high yield, RT, short-reaction-time Pd/C hydrogenation of silyl groups is described. This includes TES, TPS, TBS, TBDMS, TIPS, and TBDPS. The relative selectivity of the process has been investigated and we can show, for example, that TES, TPS, TBS, and TBDMS removal can be performed in the presence of TIPS and TBDPS. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.12.145

文献信息

• Silyl group deprotection by Pd/C/H2. A facile and selective method
  作者：Seongjin Kim、Sheila Marie Jacobo、Chih-Tsung Chang、Sophie Bellone、William S. Powell、Joshua Rokach

  DOI：10.1016/j.tetlet.2003.12.145

  日期：2004.2

  An easy, high yield, RT, short-reaction-time Pd/C hydrogenation of silyl groups is described. This includes TES, TPS, TBS, TBDMS, TIPS, and TBDPS. The relative selectivity of the process has been investigated and we can show, for example, that TES, TPS, TBS, and TBDMS removal can be performed in the presence of TIPS and TBDPS. (C) 2004 Elsevier Ltd. All rights reserved.