2-(2,2-Dimethyl-propionylamino)-5-phenyl-thiophene-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-(2,2-Dimethyl-propionylamino)-5-phenyl-thiophene-3-carboxylic acid
• 英文别名: 2-(2,2-dimethylpropanoylamino)-5-phenylthiophene-3-carboxylic acid
• 化学式: C₁₆H₁₇NO₃S
• 分子量: 303.4
• InChiKey: FYSJMBFGDRCTPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  94.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES<br/>[FR] DÉRIVÉS DE THIOPHÈNE NON FUSIONNÉS ET LEURS UTILISATIONS
  申请人：ENYO PHARMA

  公开号：WO2019154953A1

  公开（公告）日：2019-08-15

  The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

  本发明涉及一类新型非融合噻吩衍生物及其用于治疗感染、癌症、代谢性疾病、心血管疾病、铁贮存紊乱和炎症性疾病等疾病的用途。
• Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions
  申请人：Traynelis Stephen F.

  公开号：US20120028977A1

  公开（公告）日：2012-02-02

  Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds of the general Formulas A-J, and pharmaceutically acceptable salts, esters, prodrugs or derivatives thereof are disclosed.
• US20140275529A1
  申请人：——

  公开号：US20140275529A1

  公开（公告）日：2014-09-18
• NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES
  申请人：ENYO PHARMA

  公开号：US20200369655A1

  公开（公告）日：2020-11-26

  The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
• US8822462B2
  申请人：——

  公开号：US8822462B2

  公开（公告）日：2014-09-02