(4R)-4-methyl-3,4-dihydro-2H-thiochromene 1,1-dioxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: (4R)-4-methyl-3,4-dihydro-2H-thiochromene 1,1-dioxide
• 化学式: C₁₀H₁₂O₂S
• 分子量: 196.27
• InChiKey: RPAVCRAYQMOMIE-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Indole derivative used as CRTH2 inhibitor
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

  公开号：US10800765B2

  公开（公告）日：2020-10-13

  The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.

  本申请公开了一种由式（I）表示的用作 CRTH2 抑制剂的吲哚、该吲哚的药学上可接受的盐或同系物，以及其在治疗与 CRTH2 受体有关的疾病中的应用。
• FUNCTIONALIZED PYRROLIDINES AND USE THEREOF AS IAP INHIBITORS
  申请人：Laurent Alain

  公开号：US20110117081A1

  公开（公告）日：2011-05-19

  A compound of Formula (1) or a salt thereof, methods for the preparation and use of such a compound, especially as an IAP inhibitor, and related compounds, compositions, and methods.
• INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20190248770A1

  公开（公告）日：2019-08-15

  The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.
• ANTHELMINTIC HETEROCYCLIC COMPOUNDS
  申请人：Boehringer Ingelheim Animal Health USA Inc.

  公开号：US20210380591A1

  公开（公告）日：2021-12-09

  This invention provides for compounds of the formula: wherein the variables are defined herein, or salt thereof, compositions comprising these compounds, and method for the treatment, control or prevention of a parasitic infestation or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.