4-(3-Amino-2-thienyl)-buttersaeure | 101861-72-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 4-(3-Amino-2-thienyl)-buttersaeure
• 英文别名: 4-(3-amino-thiophen-2-yl)-butyric acid；4-(3-Aminothiophen-2-yl)butanoic acid
• CAS: 101861-72-7
• 化学式: C₈H₁₁NO₂S
• 分子量: 185.247
• InChiKey: XORBTNKJGCHZCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  91.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CONJUGATES AND THERAPEUTIC USES THEREOF
  申请人：The Walter and Eliza Hall Institute of Medical Research

  公开号：EP1781689A1

  公开（公告）日：2007-05-09
• COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETES
  申请人：Dia-B Tech Limited

  公开号：EP1962882A1

  公开（公告）日：2008-09-03
• Peptides and therapeutic uses thereof
  申请人：Baell Jonathan

  公开号：US20070032417A1

  公开（公告）日：2007-02-08

  Conformationally constrained peptides that mimic BH3-only proteins, compositions containing them and their use in the regulation of cell death are disclosed. The conformationally constrained peptides are capable of binding to and neutralising pro-survival Bcl-2 proteins. Processes for preparing the conformationally constrained peptides and their use in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.
• Conjugates And Therapeutic Uses Thereof
  申请人：Baell Jonathan

  公开号：US20070197430A1

  公开（公告）日：2007-08-23

  Conformationally constrained peptides that mimic BH3-only proteins and their conjugation to antibodies and other cell targeting compounds, compositions containing the conjugates and their use in the regulation of cell death are disclosed. The conformationally constrained peptides are capable of binding to and neutralising pro-survival Bcl-2 proteins. Processes for preparing the conformationally constrained peptides conjugated to antibodies and other cell targeting compounds and use of the conjugates in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.
• [EN] PEPTIDES AND THERAPEUTIC USES THEREOF<br/>[FR] PEPTIDES ET UTILISATIONS THERAPEUTIQUES DE CEUX-CI
  申请人：INST MEDICAL W & E HALL

  公开号：WO2004058804A1

  公开（公告）日：2004-07-15

  Conformationally constrained peptides that mimic BH3-only proteins, compositions containing them and their use in the regulation of cell death are disclosed. The conformationally constrained peptides are capable of binding to and neutralising pro-survival Bcl-2 proteins. Processes for preparing the conformationally constrained peptides and their use in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.